League Leaders - Offense
| Passing Yards | Complete List | |
Jared Goff
|
1. Jared Goff, DET | 708 |
| 2. Kyler Murray, NYG | 682 | |
| 3. Dak Prescott, DAL | 642 | |
| 4. Kenny Pickett, PIT | 630 | |
| 5. Justin Herbert, LAC | 532 | |
| Rushing Yards | Complete List | |
Josh Jacobs
|
1. Josh Jacobs, LV | 259 |
| 2. Austin Ekeler, LAC | 227 | |
| 3. Ezekiel Elliott, DAL | 197 | |
| 4. Nick Chubb, CLE | 156 | |
| 5. Javonte Williams, DEN | 140 | |
| Receiving Yards | Complete List | |
Drake London
|
1. Drake London, ATL | 240 |
| 2. Mike Williams, LAC | 218 | |
| 3. CeeDee Lamb, DAL | 203 | |
| 4. Najee Harris, PIT | 198 | |
| 5. Amon-Ra St. Brown, DET | 195 | |
League Leaders - Defense
| Tackles | Complete List | |
Adoree' Jackson
|
1. Adoree' Jackson, NYG | 15 |
| 2. Bobby Okereke, PHI | 13 | |
| 3. Leighton Vander Esch, NYG | 12 | |
| 4. Cameron Sutton, PIT | 11 | |
| 5. Isaiah Simmons, ARI | 11 | |
| Sacks | Complete List | |
Joey Bosa
|
1. Joey Bosa, LAC | 4 |
| 2. T.J. Watt, PIT | 3 | |
| 3. Chase Young, WAS | 3 | |
| 4. Khalil Mack, LAC | 3 | |
| 5. Vince Coleman, CLE | 2 | |
| Interceptions | Complete List | |
Justin Simmons
|
1. Justin Simmons, DEN | 3 |
| 2. Kyle Fuller, MIN | 3 | |
| 3. JC Jackson, LAC | 3 | |
| 4. Isaiah Simmons, ARI | 2 | |
| 5. Chandon Sullivan, MIN | 2 | |