League Leaders - Offense
| Passing Yards | Complete List | |
Kyler Murray
|
1. Kyler Murray, ATL | 1883 |
| 2. Jamie Thomas, LV | 1869 | |
| 3. Mac Jones, SF | 1866 | |
| 4. Matthew Stafford, CIN | 1732 | |
| 5. Trevor Lawrence, NE | 1727 | |
| Rushing Yards | Complete List | |
Jonathan Taylor
|
1. Jonathan Taylor, DET | 868 |
| 2. Alfred Johnson, KC | 750 | |
| 3. Nick Chubb, JAX | 686 | |
| 4. Najee Harris, LAR | 681 | |
| 5. Joe Mixon, ARI | 580 | |
| Receiving Yards | Complete List | |
Tyreek Hill
|
1. Tyreek Hill, SF | 699 |
| 2. George Kittle, GB | 670 | |
| 3. Jaylen Waddle, GB | 651 | |
| 4. Hunter Renfrow, LAR | 649 | |
| 5. Tyquan Thornton, ATL | 625 | |
League Leaders - Defense
| Tackles | Complete List | |
Lavonte David
|
1. Lavonte David, DAL | 42 |
| 2. Deion Jones, IND | 38 | |
| 3. Chad Muma, ARI | 37 | |
| 4. Myles Jack, PHI | 35 | |
| 5. Troy Andersen, NYG | 34 | |
| Sacks | Complete List | |
Myles Garrett
|
1. Myles Garrett, LAR | 9 |
| 2. Da'Ron Payne, MIA | 9 | |
| 3. Micah Parsons, TB | 8 | |
| 4. Josh Sweat, DEN | 8 | |
| 5. Brian Burns, NE | 8 | |
| Interceptions | Complete List | |
Adrian Amos
|
1. Adrian Amos, JAX | 7 |
| 2. Justin Simmons, JAX | 7 | |
| 3. Stephon Gilmore, PIT | 6 | |
| 4. Trevon Diggs, KC | 5 | |
| 5. Shaquill Griffin, CIN | 5 | |