League Leaders - Offense
| Passing Yards | Complete List | |
Matty Ice
|
1. Matty Ice, VAN | 723 |
| 2. Lamar Jackson, BAL | 589 | |
| 3. Robert Marks, SF | 544 | |
| 4. Hendon Hooker, DET | 453 | |
| 5. Joe Burrow, CIN | 449 | |
| Rushing Yards | Complete List | |
Rachaad White
|
1. Rachaad White, TB | 188 |
| 2. J.K. Dobbins, BAL | 187 | |
| 3. Alvin Kamara, NO | 174 | |
| 4. Jahmyr Gibbs, DET | 132 | |
| 5. Nick Chubb, SJU | 106 | |
| Receiving Yards | Complete List | |
Aries Portis
|
1. Aries Portis, IND | 160 |
| 2. George Pickens, PIT | 135 | |
| 3. Kyle Pitts, HST | 135 | |
| 4. Quentin Johnston, LAC | 127 | |
| 5. Drake London, VAN | 123 | |
League Leaders - Defense
| Tackles | Complete List | |
Nick Bolton
|
1. Nick Bolton, TKY2 | 12 |
| 2. Shaq Thompson, BKN | 11 | |
| 3. Daxton Hill, CIN | 11 | |
| 4. Deion Jones, VAN | 10 | |
| 5. Cam Taylor-Britt, CIN | 10 | |
| Sacks | Complete List | |
Maxx Crosby
|
1. Maxx Crosby, LV | 3 |
| 2. Myles Murphy, CIN | 3 | |
| 3. T.J. Watt, PIT | 3 | |
| 4. Khalil Mack, LAC | 2 | |
| 5. Cade Smith, TB | 2 | |
| Interceptions | Complete List | |
Jaylon Johnson
|
1. Jaylon Johnson, CHI | 2 |
| 2. Jaycee Horn, BKN | 2 | |
| 3. A.J. Terrell Jr, VAN | 2 | |
| 4. Dre Greenlaw, SF | 1 | |
| 5. Grant Delpit, SF | 1 | |