League Leaders - Offense
| Passing Yards | Complete List | |
Patrick Mahomes
|
1. Patrick Mahomes, KC | 1828 |
| 2. Joe Burrow, CIN | 1718 | |
| 3. Justin Fields, CHI | 1678 | |
| 4. Jalen Hurts, IND | 1603 | |
| 5. Trevor Lawrence, JAX | 1549 | |
| Rushing Yards | Complete List | |
Jonathan Taylor
|
1. Jonathan Taylor, PHI | 528 |
| 2. Nick Chubb, CLE | 487 | |
| 3. Dalvin Cook, MIN | 459 | |
| 4. Kareem Hunt, BAL | 459 | |
| 5. Josh Jacobs, LV | 428 | |
| Receiving Yards | Complete List | |
Drake London
|
1. Drake London, ATL | 671 |
| 2. Mecole Hardman, KC | 637 | |
| 3. Deebo Samuel, SF | 611 | |
| 4. Keenan Allen, LAC | 581 | |
| 5. Justin Jefferson, MIN | 570 | |
League Leaders - Defense
| Tackles | Complete List | |
Foyesade Oluokun
|
1. Foyesade Oluokun, JAX | 38 |
| 2. Nolan Smith, DET | 34 | |
| 3. Bobby Wagner, LAR | 30 | |
| 4. Drue Tranquill, SEA | 29 | |
| 5. Kenneth Murray Jr, LAC | 28 | |
| Sacks | Complete List | |
Joey Bosa
|
1. Joey Bosa, LAC | 9 |
| 2. Odafe Oweh, BAL | 6 | |
| 3. Micah Parsons, DAL | 6 | |
| 4. Nick Bosa, SF | 6 | |
| 5. Maxx Crosby, LV | 6 | |
| Interceptions | Complete List | |
Budda Baker
|
1. Budda Baker, ARI | 6 |
| 2. Julian Love, NYG | 6 | |
| 3. Chidobe Awuzie, CIN | 5 | |
| 4. Justin Reid, KC | 5 | |
| 5. Kyle Dugger, NE | 5 | |