League Leaders - Offense
| Passing Yards | Complete List | |
C.J. Stroud
|
1. C.J. Stroud, SA | 2184 |
| 2. Cody Kiernan, TB | 2153 | |
| 3. Max Duggan, RIO | 2072 | |
| 4. Deshaun Watson, ANC | 2038 | |
| 5. Johnny Dinkins, TKY2 | 1987 | |
| Rushing Yards | Complete List | |
Travis Etienne Jr
|
1. Travis Etienne Jr, JAX | 916 |
| 2. LaDainian Tomlinson II, SDG2 | 877 | |
| 3. Tony Pollard, HST3 | 863 | |
| 4. Breece Hall, ORL | 744 | |
| 5. Ezekiel Crawford, NO | 738 | |
| Receiving Yards | Complete List | |
Brian Coleman
|
1. Brian Coleman, TKY2 | 792 |
| 2. Amari Cooper, ANC | 762 | |
| 3. Tyrese Willis, SA | 699 | |
| 4. Kasey Hughes, SA | 696 | |
| 5. Kyle Pitts, ALB | 668 | |
League Leaders - Defense
| Tackles | Complete List | |
Aaron Poole
|
1. Aaron Poole, PAR2 | 37 |
| 2. Drew Sanders, DEN | 37 | |
| 3. Dre Greenlaw, MEM | 32 | |
| 4. Jack Campbell, DET | 31 | |
| 5. Rashaun DeBose, BA | 29 | |
| Sacks | Complete List | |
Josh Allen
|
1. Josh Allen, JAX | 8 |
| 2. Myles Garrett, ANC | 7 | |
| 3. Will McDonald IV, ORL | 6 | |
| 4. Jonathan Swift, DEN | 5 | |
| 5. Jaelan Phillips, PAR2 | 5 | |
| Interceptions | Complete List | |
Dane Belton
|
1. Dane Belton, RIO | 7 |
| 2. Mike Jackson Sr, SEA | 6 | |
| 3. Tariq Woolen, SEA | 6 | |
| 4. Lorenzo Jones, LAR | 6 | |
| 5. Stephon Gilmore, HST3 | 6 | |