League Leaders - Offense
| Passing Yards | Complete List | |
John Barden
|
1. John Barden, VAN | 421 |
| 2. Sam McLean, SEA | 413 | |
| 3. C.J. Stroud, HOU | 367 | |
| 4. Dillon Dickinson, TOR | 359 | |
| 5. Glenn Black, DEN | 326 | |
| Rushing Yards | Complete List | |
Tyrion Davis-Price
|
1. Tyrion Davis-Price, IND | 151 |
| 2. Deshawn Matthews, VAN | 105 | |
| 3. Kenneth Walker III, SEA | 74 | |
| 4. Javonte Williams, DEN | 71 | |
| 5. Jonathan Taylor, TOR | 70 | |
| Receiving Yards | Complete List | |
D.J. Moore
|
1. D.J. Moore, HOU | 197 |
| 2. Will Barrow, VAN | 186 | |
| 3. Ross Ryans, VAN | 174 | |
| 4. Levi Gregory, TOR | 173 | |
| 5. Jaylen Waddle, MON | 133 | |
League Leaders - Defense
| Tackles | Complete List | |
Al Cunningham
|
1. Al Cunningham, MIA | 8 |
| 2. Zach Crocker, TOR | 7 | |
| 3. Brandon Jones, MIA | 6 | |
| 4. Danielle Hunter, MON | 6 | |
| 5. Deommodore Lenoir, SF | 5 | |
| Sacks | Complete List | |
Danielle Hunter
|
1. Danielle Hunter, MON | 4 |
| 2. Manny Casey, SEA | 2 | |
| 3. Fred Warner, SF | 1 | |
| 4. Felix McFadden, IND | 1 | |
| 5. Joey Bosa, TOR | 1 | |
| Interceptions | Complete List | |
Michael Carter II
|
1. Michael Carter II, TOR | 1 |
| 2. DJ Turner, TOR | 1 | |
| 3. Talanoa Hufanga, SF | 1 | |
| 4. Jalen Ramsey, DEN | 1 | |
| 5. Mack Wilson Sr, SF | 1 | |