League Leaders - Offense
| Passing Yards | Complete List | |
Trevor Lawrence
|
1. Trevor Lawrence, JAX | 2078 |
| 2. Joe Burrow, CIN | 2070 | |
| 3. Drake Maye, NE | 2047 | |
| 4. J.J. McCarthy, MIN | 2045 | |
| 5. Anthony Richardson, IND | 1997 | |
| Rushing Yards | Complete List | |
Travis Etienne Jr
|
1. Travis Etienne Jr, JAX | 833 |
| 2. Zach Charbonnet, NYG | 764 | |
| 3. Justin Stanford, DAL | 736 | |
| 4. Trey Benson, ARI | 636 | |
| 5. Marshal Jackson, LAR | 631 | |
| Receiving Yards | Complete List | |
Amon-Ra St. Brown
|
1. Amon-Ra St. Brown, IND | 736 |
| 2. Marvin Harrison Jr, ARI | 705 | |
| 3. CeeDee Lamb, DAL | 631 | |
| 4. Ja'Marr Chase, CIN | 629 | |
| 5. Isaiah Williams, MIN | 618 | |
League Leaders - Defense
| Tackles | Complete List | |
Terrel Bernard
|
1. Terrel Bernard, BUF | 42 |
| 2. Zaire Franklin, IND | 42 | |
| 3. Drew Sanders, DEN | 40 | |
| 4. Tre'von Moehrig, LV | 36 | |
| 5. Edgerrin Cooper, GB | 36 | |
| Sacks | Complete List | |
Josh Uche
|
1. Josh Uche, NE | 13 |
| 2. Rodney Douglas, DEN | 10 | |
| 3. Nnamdi Madubuike, BAL | 9 | |
| 4. Will Westerman, DET | 9 | |
| 5. Myles Garrett, CLE | 7 | |
| Interceptions | Complete List | |
Trevon Diggs
|
1. Trevon Diggs, DAL | 7 |
| 2. DaRon Bland, DAL | 5 | |
| 3. Jartavius Martin, WAS | 4 | |
| 4. Asante Samuel Jr, LAC | 3 | |
| 5. DeMarvion Overshown, WAS | 3 | |