League Leaders - Offense
| Passing Yards | Complete List | |
Desmond Ridder
|
1. Desmond Ridder, ATL | 3713 |
| 2. Patrick Mahomes, KC | 3662 | |
| 3. Dak Prescott, DAL | 3528 | |
| 4. Mac Jones, NE | 3499 | |
| 5. Trevor Lawrence, JAX | 3490 | |
| Rushing Yards | Complete List | |
Dalvin Cook
|
1. Dalvin Cook, MIN | 1259 |
| 2. Javonte Williams, DEN | 1241 | |
| 3. Jonathan Taylor, IND | 1149 | |
| 4. Nick Chubb, CLE | 1143 | |
| 5. Christian McCaffrey, CAR | 1134 | |
| Receiving Yards | Complete List | |
CeeDee Lamb
|
1. CeeDee Lamb, DAL | 1513 |
| 2. Stefon Diggs, BUF | 1416 | |
| 3. Mecole Hardman, KC | 1189 | |
| 4. D.J. Moore, CAR | 1162 | |
| 5. Courtland Sutton, DEN | 975 | |
League Leaders - Defense
| Tackles | Complete List | |
Devin White
|
1. Devin White, TB | 82 |
| 2. Foyesade Oluokun, JAX | 71 | |
| 3. Antoine Winfield Jr, TB | 58 | |
| 4. Alexander Johnson, DET | 56 | |
| 5. Akeem Dent, TB | 56 | |
| Sacks | Complete List | |
Joey Bosa
|
1. Joey Bosa, LAC | 13 |
| 2. T.J. Watt, PIT | 13 | |
| 3. Will Anderson Jr., ARI | 13 | |
| 4. Cameron Heyward, PIT | 11 | |
| 5. Chase Young, WAS | 11 | |
| Interceptions | Complete List | |
Bryce Hall
|
1. Bryce Hall, NYJ | 12 |
| 2. Jonathan Jones, NE | 9 | |
| 3. Justin Simmons, DEN | 9 | |
| 4. Isaiah Simmons, ARI | 9 | |
| 5. Chidobe Awuzie, CIN | 9 | |