| Player Passing Statistics | ||||||||||
| Team | Cmp | Att | Cmp% | Yds | AVG | Long | TD | Int | Sack | Rate |
| 1. C.J. Stroud, HOU | 20 | 26 | 76.9 | 323 | 12.4 | 46 | 2 | 3 | 2 | 105.0 |
| 2. Anthony Richardson, MIA | 17 | 24 | 70.8 | 298 | 12.4 | 37 | 1 | 3 | 1 | 86.6 |
| 3. Justin Fields, CHI | 13 | 20 | 65.0 | 253 | 12.7 | 63 | 2 | 1 | 2 | 120.8 |
| 4. Patrick Mahomes, KC | 11 | 17 | 64.7 | 344 | 20.2 | 87 | 3 | 1 | 7 | 123.1 |
| 5. Malik Willis, SF | 20 | 31 | 64.5 | 417 | 13.5 | 87 | 6 | 1 | 1 | 134.2 |
| 6. Michael Devlin, NE | 19 | 33 | 57.6 | 352 | 10.7 | 75 | 2 | 4 | 1 | 74.9 |
| 7. Trey Lance, DET | 15 | 29 | 51.7 | 414 | 14.3 | 84 | 5 | 1 | 4 | 122.7 |
| 8. Joe Burrow, GB | 17 | 33 | 51.5 | 426 | 12.9 | 87 | 4 | 3 | 5 | 98.8 |