League Leaders - Offense
| Passing Yards | Complete List | |
Dorian Stephenson
|
1. Dorian Stephenson, DEN | 5003 |
| 2. Patrick Mahomes, KC | 4719 | |
| 3. Jayden Daniels, WAS | 4699 | |
| 4. Justin Herbert, LAC | 4524 | |
| 5. Joe Burrow, CIN | 4457 | |
| Rushing Yards | Complete List | |
Josh Jacobs
|
1. Josh Jacobs, GB | 2224 |
| 2. Kenneth Walker III, SEA | 1563 | |
| 3. Bijan Robinson, ATL | 1552 | |
| 4. Jonathon Brooks, CAR | 1484 | |
| 5. Jahmyr Gibbs, DET | 1483 | |
| Receiving Yards | Complete List | |
Dillon Poole
|
1. Dillon Poole, MIA | 1774 |
| 2. Bobby Manning, LAC | 1759 | |
| 3. Greg Dulcich, DEN | 1442 | |
| 4. Justin Jefferson, MIN | 1401 | |
| 5. Rashawn Ridley, MIN | 1391 | |
League Leaders - Defense
| Tackles | Complete List | |
Malcolm Rodriguez
|
1. Malcolm Rodriguez, CHI | 68 |
| 2. Divine Deablo, LV | 65 | |
| 3. Edgerrin Cooper, GB | 65 | |
| 4. Spencer Turner, NO | 60 | |
| 5. Markquese Bell, DAL | 58 | |
| Sacks | Complete List | |
Micah Parsons
|
1. Micah Parsons, NE | 14 |
| 2. Quinnen Williams, NYJ | 14 | |
| 3. Tyler Flowers, GB | 13 | |
| 4. Darius Robinson, ARI | 12 | |
| 5. Amir Riddick, NYJ | 12 | |
| Interceptions | Complete List | |
James Williams
|
1. James Williams, DEN | 15 |
| 2. Jaylon Johnson, CHI | 13 | |
| 3. Justin Reid, KC | 13 | |
| 4. Trevin Wallace, CAR | 12 | |
| 5. Brian Branch, DEN | 12 | |