League Leaders - Offense
| Passing Yards | Complete List | |
Kyler Murray
|
1. Kyler Murray, ARI | 4905 |
| 2. Dorian Stephenson, DEN | 4855 | |
| 3. Lloyd Peters, MIA | 4835 | |
| 4. Dak Prescott, NE | 4684 | |
| 5. Bryce Young, CAR | 4543 | |
| Rushing Yards | Complete List | |
Josh Jacobs
|
1. Josh Jacobs, GB | 2016 |
| 2. Ben Dansby, MIN | 1892 | |
| 3. Stephen Glover, BUF | 1618 | |
| 4. Najee Randolph, NO | 1490 | |
| 5. Isiah Pacheco, TB | 1475 | |
| Receiving Yards | Complete List | |
Rashid Shaheed
|
1. Rashid Shaheed, ARI | 1892 |
| 2. Floyd Long, TEN | 1438 | |
| 3. Kyle Pitts, ATL | 1349 | |
| 4. Greg Dulcich, DEN | 1344 | |
| 5. Dillon Poole, MIA | 1330 | |
League Leaders - Defense
| Tackles | Complete List | |
Junior Colson
|
1. Junior Colson, LAC | 110 |
| 2. J.P. Farmer, LAC | 87 | |
| 3. Divine Deablo, LV | 73 | |
| 4. Trevin Wallace, LV | 71 | |
| 5. Jeremiah Owusu-Koramoah, CLE | 69 | |
| Sacks | Complete List | |
Will Anderson Jr
|
1. Will Anderson Jr, HOU | 15 |
| 2. Jared Verse, LAR | 14 | |
| 3. Jermaine Johnson II, NYJ | 13 | |
| 4. Osa Odighizuwa, JAX | 12 | |
| 5. Joey Bosa, LAR | 12 | |
| Interceptions | Complete List | |
Jamin Davis
|
1. Jamin Davis, WAS | 11 |
| 2. Roger McCreary, TEN | 11 | |
| 3. Emmanuel Forbes Jr, WAS | 11 | |
| 4. Paulson Adebo, HOU | 10 | |
| 5. Terrion Arnold, DET | 10 | |