League Leaders - Offense
| Passing Yards | Complete List | |
Aaron Rodgers
|
1. Aaron Rodgers, PHI | 4908 |
| 2. Joe Burrow, NO | 4778 | |
| 3. Trevor Lawrence, NE | 4344 | |
| 4. Baker Mayfield, JAX | 4069 | |
| 5. Josh Allen, CLE | 3976 | |
| Rushing Yards | Complete List | |
Saquon Barkley
|
1. Saquon Barkley, CIN | 1552 |
| 2. Tank Bigsby, BAL | 1106 | |
| 3. Travis Etienne Jr, TEN | 1026 | |
| 4. Kenneth Walker III, NE | 936 | |
| 5. Aaron Jones, SF | 933 | |
| Receiving Yards | Complete List | |
Mike Evans
|
1. Mike Evans, NO | 1769 |
| 2. CeeDee Lamb, NYG | 1391 | |
| 3. Kyle Pitts, PHI | 1326 | |
| 4. Xavier Worthy, DEN | 1268 | |
| 5. Cooper Kupp, LAC | 1249 | |
League Leaders - Defense
| Tackles | Complete List | |
Fred Warner
|
1. Fred Warner, DET | 60 |
| 2. Malik Mustapha, IND | 51 | |
| 3. Demario Davis, NYJ | 51 | |
| 4. Daiyan Henley, ARI | 49 | |
| 5. Patrick Queen, DAL | 48 | |
| Sacks | Complete List | |
Myles Garrett
|
1. Myles Garrett, BAL | 17 |
| 2. Lewis Cine, PHI | 16 | |
| 3. Chris Jones, IND | 11 | |
| 4. Greg Rousseau, BAL | 11 | |
| 5. DeMarcus Lawrence, PHI | 10 | |
| Interceptions | Complete List | |
Zyon McCollum
|
1. Zyon McCollum, CLE | 10 |
| 2. Jaycee Horn, NE | 9 | |
| 3. Adoree' Jackson, CIN | 9 | |
| 4. Tyler Nubin, MIN | 8 | |
| 5. Trent McDuffie, CHI | 8 | |