League Leaders - Offense
| Passing Yards | Complete List | |
Malik Willis
|
1. Malik Willis, CHI | 1162 |
| 2. Justin Herbert, LAC | 999 | |
| 3. Desmond Ridder, DAL | 915 | |
| 4. Quinn Ewers, CAR | 787 | |
| 5. C.J. Stroud, KC | 647 | |
| Rushing Yards | Complete List | |
Tyrion Davis-Price
|
1. Tyrion Davis-Price, MIN | 345 |
| 2. Jonathan Taylor, JAX | 274 | |
| 3. Christian McCaffrey, PHI | 195 | |
| 4. Ben Canady, GB | 178 | |
| 5. Raheim Sanders, TB | 167 | |
| Receiving Yards | Complete List | |
Ja'Marr Chase
|
1. Ja'Marr Chase, CAR | 495 |
| 2. Darren Waller, KC | 357 | |
| 3. DeAndre Hopkins, CHI | 315 | |
| 4. Matthew Campbell, DAL | 306 | |
| 5. Ali Jennings, CHI | 291 | |
League Leaders - Defense
| Tackles | Complete List | |
Amani Hooker
|
1. Amani Hooker, CAR | 9 |
| 2. Trevon Diggs, KC | 8 | |
| 3. Jamel Dean, LAC | 7 | |
| 4. Nate Wiggins, LAC | 6 | |
| 5. Derwin James Jr, DAL | 6 | |
| Sacks | Complete List | |
Jeffery Simmons
|
1. Jeffery Simmons, DAL | 6 |
| 2. Shaquil Barrett, LAC | 4 | |
| 3. Nick Bosa, DAL | 3 | |
| 4. Ed Oliver, LAC | 3 | |
| 5. Danielle Hunter, CHI | 2 | |
| Interceptions | Complete List | |
Kyle Dugger
|
1. Kyle Dugger, CAR | 6 |
| 2. Kyle Hamilton, DAL | 5 | |
| 3. Terrion Arnold, CAR | 4 | |
| 4. Kelee Ringo, MIA | 3 | |
| 5. Isaiah Simmons, CHI | 3 | |