League Leaders - Offense
| Passing Yards | Complete List | |
Justin Herbert
|
1. Justin Herbert, LAC | 1205 |
| 2. C.J. Stroud, HOU | 1143 | |
| 3. Dak Prescott, DAL | 1112 | |
| 4. Patrick Mahomes, KC | 1102 | |
| 5. J.J. McCarthy, MIN | 1036 | |
| Rushing Yards | Complete List | |
Joe Mixon
|
1. Joe Mixon, HOU | 372 |
| 2. Devin Singletary, NYG | 338 | |
| 3. Nick Chubb, CLE | 337 | |
| 4. Josh Jacobs, GB | 333 | |
| 5. Derrick Henry, BAL | 327 | |
| Receiving Yards | Complete List | |
CeeDee Lamb
|
1. CeeDee Lamb, DAL | 478 |
| 2. Justin Jefferson, MIN | 451 | |
| 3. Brandon Aiyuk, SF | 423 | |
| 4. Jakobi Meyers, LV | 380 | |
| 5. Rashee Rice, KC | 340 | |
League Leaders - Defense
| Tackles | Complete List | |
Germaine Pratt
|
1. Germaine Pratt, CIN | 30 |
| 2. Willie Gay, NO | 28 | |
| 3. Fred Warner, SF | 28 | |
| 4. C.J. Mosley, NYJ | 27 | |
| 5. Dre Greenlaw, SF | 27 | |
| Sacks | Complete List | |
Micah Parsons
|
1. Micah Parsons, DAL | 7 |
| 2. DeForest Buckner, IND | 5 | |
| 3. Maxx Crosby, LV | 5 | |
| 4. Khalil Mack, LAC | 5 | |
| 5. Jaelan Phillips, MIA | 4 | |
| Interceptions | Complete List | |
Javon Bullard
|
1. Javon Bullard, GB | 3 |
| 2. Sauce Gardner, NYJ | 3 | |
| 3. Jessie Bates III, ATL | 3 | |
| 4. Deonte Banks, NYG | 2 | |
| 5. Dre Greenlaw, SF | 2 | |