League Leaders - Offense
| Passing Yards | Complete List | |
Tavien St. Clair
|
1. Tavien St. Clair, SF | 3110 |
| 2. Caleb Williams, CHI | 2600 | |
| 3. Jaxson Dart, NYJ | 2569 | |
| 4. Brock Purdy, NE | 2471 | |
| 5. Jared Curtis, ATL | 2464 | |
| Rushing Yards | Complete List | |
De'Von Achane
|
1. De'Von Achane, MIA | 744 |
| 2. Justice Haynes, DEN | 727 | |
| 3. Girard Pringle Jr, SEA | 670 | |
| 4. Jadarian Price, LV | 670 | |
| 5. Alex Chambers, NE | 643 | |
| Receiving Yards | Complete List | |
Zach Harris
|
1. Zach Harris, SF | 1131 |
| 2. Ja'Marr Chase, CIN | 854 | |
| 3. Micah Hudson, GB | 774 | |
| 4. CeeDee Lamb, NE | 713 | |
| 5. Carnell Tate, BAL | 677 | |
League Leaders - Defense
| Tackles | Complete List | |
Jaylon Carlies
|
1. Jaylon Carlies, MIN | 65 |
| 2. Steven Lambert, BAL | 58 | |
| 3. Edgerrin Cooper, IND | 54 | |
| 4. Tyler Atkinson, NYG | 51 | |
| 5. Lander Barton, NYJ | 50 | |
| Sacks | Complete List | |
T.J. Parker
|
1. T.J. Parker, LV | 15 |
| 2. Travon Walker, NO | 8 | |
| 3. Nick Bosa, JAX | 8 | |
| 4. Kenneth Grant, WAS | 8 | |
| 5. Hezekiah Harris, DEN | 7 | |
| Interceptions | Complete List | |
Drew Sanders
|
1. Drew Sanders, DEN | 6 |
| 2. Tre'von Moehrig, SF | 5 | |
| 3. Tommi Hillman, MIA | 4 | |
| 4. Kalen Lowry, SF | 4 | |
| 5. Arvell Reese, DEN | 4 | |