League Leaders - Offense
| Passing Yards | Complete List | |
Jalen Milroe
|
1. Jalen Milroe, DEN | 1996 |
| 2. Anthony Richardson, IND | 1859 | |
| 3. Bo Nix, BUF | 1722 | |
| 4. Kaidon Salter, TEN | 1706 | |
| 5. Jared Curtis, ATL | 1706 | |
| Rushing Yards | Complete List | |
Tyjae Spears
|
1. Tyjae Spears, MIN | 680 |
| 2. Bijan Robinson, ATL | 630 | |
| 3. Shekai Mills-Knight, DET | 620 | |
| 4. Kenneth Walker III, LV | 611 | |
| 5. TreVeyon Henderson, CHI | 587 | |
| Receiving Yards | Complete List | |
Jeremiah Smith
|
1. Jeremiah Smith, NE | 884 |
| 2. Cassidee Miles, TEN | 878 | |
| 3. Ryan Williams, IND | 785 | |
| 4. Rome Odunze, CHI | 740 | |
| 5. Tyler Harrell, NYJ | 719 | |
League Leaders - Defense
| Tackles | Complete List | |
Terrel Bernard
|
1. Terrel Bernard, CLE | 54 |
| 2. Nakobe Dean, KC | 51 | |
| 3. Jakaleb Faulk, KC | 49 | |
| 4. Jeremiah Owusu-Koramoah, CLE | 43 | |
| 5. Sammy Brown, TB | 41 | |
| Sacks | Complete List | |
Aidan Hutchinson
|
1. Aidan Hutchinson, ATL | 11 |
| 2. Ruke Orhorhoro, ATL | 10 | |
| 3. James Pearce Jr, PIT | 8 | |
| 4. Josh Hines-Allen, PHI | 6 | |
| 5. Maxx Crosby, LV | 6 | |
| Interceptions | Complete List | |
Sauce Gardner
|
1. Sauce Gardner, NYJ | 6 |
| 2. Talanoa Hufanga, SF | 4 | |
| 3. Nyles Foster, JAX | 4 | |
| 4. Davison Igbinosun, SF | 4 | |
| 5. Zabien Brown, DET | 4 | |