League Leaders - Offense
| Passing Yards | Complete List | |
Kyler Murray
|
1. Kyler Murray, ARI | 3956 |
| 2. Arch Manning, PHI | 3779 | |
| 3. Brock Purdy, SF | 3486 | |
| 4. Trevor Lawrence, JAX | 3126 | |
| 5. Andy Mann, LV | 3087 | |
| Rushing Yards | Complete List | |
Breece Hall
|
1. Breece Hall, NYJ | 825 |
| 2. Isiah Pacheco, ARI | 733 | |
| 3. Mike Jones, MIN | 713 | |
| 4. Bijan Robinson, ATL | 703 | |
| 5. Josh Jacobs, NYG | 671 | |
| Receiving Yards | Complete List | |
Xavier Worthy
|
1. Xavier Worthy, ARI | 1939 |
| 2. Ricky Pearsall, SF | 1386 | |
| 3. George Pickens, PHI | 1224 | |
| 4. Matthew Hardy, ARI | 993 | |
| 5. Chris Norwood, PHI | 987 | |
League Leaders - Defense
| Tackles | Complete List | |
Edgerrin Cooper
|
1. Edgerrin Cooper, GB | 62 |
| 2. Brian Orakpo II, TEN | 60 | |
| 3. Jeremiah Owusu-Koramoah, DET | 60 | |
| 4. Matt Milano, TEN | 59 | |
| 5. Tory Hall, PHI | 54 | |
| Sacks | Complete List | |
BJ Ojulari
|
1. BJ Ojulari, ARI | 15 |
| 2. Derrick Brooks, TB | 12 | |
| 3. Aidan Hutchinson, DET | 12 | |
| 4. Charles Haley, SF | 11 | |
| 5. Logan Wilson, CIN | 11 | |
| Interceptions | Complete List | |
Payton Wilson
|
1. Payton Wilson, LAC | 6 |
| 2. Otis Goodwin, HOU | 5 | |
| 3. Nick Shirley, SF | 5 | |
| 4. Denzel Ward, CLE | 4 | |
| 5. Antoine Winfield Jr, CLE | 4 | |