League Leaders - Offense
| Passing Yards | Complete List | |
Kyler Murray
|
1. Kyler Murray, ARI | 5129 |
| 2. Arch Manning, PHI | 5057 | |
| 3. Brock Purdy, SF | 4678 | |
| 4. Trevor Lawrence, JAX | 4545 | |
| 5. Dak Prescott, DAL | 4468 | |
| Rushing Yards | Complete List | |
Bijan Robinson
|
1. Bijan Robinson, ATL | 1288 |
| 2. Breece Hall, NYJ | 1242 | |
| 3. De'Von Achane, LV | 1159 | |
| 4. Josh Jacobs, NYG | 1156 | |
| 5. Jahmyr Gibbs, DET | 1098 | |
| Receiving Yards | Complete List | |
Xavier Worthy
|
1. Xavier Worthy, ARI | 3098 |
| 2. Ricky Pearsall, SF | 2068 | |
| 3. George Pickens, PHI | 1733 | |
| 4. Rashee Rice, KC | 1659 | |
| 5. Jameson Williams, PHI | 1543 | |
League Leaders - Defense
| Tackles | Complete List | |
Edgerrin Cooper
|
1. Edgerrin Cooper, GB | 103 |
| 2. Jeremiah Owusu-Koramoah, DET | 99 | |
| 3. Kamryn Woodley, ATL | 97 | |
| 4. Jadeveon Clowney, SEA | 97 | |
| 5. Divine Deablo, PIT | 90 | |
| Sacks | Complete List | |
T.J. Watt
|
1. T.J. Watt, PIT | 23 |
| 2. Maxx Crosby, TB | 22 | |
| 3. BJ Ojulari, ARI | 18 | |
| 4. Derrick Brooks, TB | 18 | |
| 5. Gerald Christmas, BAL | 18 | |
| Interceptions | Complete List | |
Payton Wilson
|
1. Payton Wilson, LAC | 7 |
| 2. Jalen Ramsey, PIT | 7 | |
| 3. Marquez Nobles, DEN | 6 | |
| 4. Nick Shirley, SF | 6 | |
| 5. Cole Bishop, CIN | 6 | |