League Leaders - Offense
| Passing Yards | Complete List | |
Dak Prescott
|
1. Dak Prescott, DAL | 6041 |
| 2. Greg Britton, GB | 5704 | |
| 3. Patrick Mahomes, KC | 5371 | |
| 4. Matt Corral, MIN | 5361 | |
| 5. Joe Burrow, LV | 5254 | |
| Rushing Yards | Complete List | |
Derrick Henry
|
1. Derrick Henry, TEN | 1724 |
| 2. Jonathan Taylor, NO | 1642 | |
| 3. Alvin Kamara, IND | 1622 | |
| 4. Saquon Barkley, NYG | 1397 | |
| 5. Leonard Fournette, TB | 1382 | |
| Receiving Yards | Complete List | |
Christian Watson
|
1. Christian Watson, GB | 2569 |
| 2. Danny McPherson, DAL | 2053 | |
| 3. Russell Gage Jr, TB | 2052 | |
| 4. Speedy Klaxter-Warren, CAR | 1997 | |
| 5. D.K. Metcalf, SEA | 1956 | |
League Leaders - Defense
| Tackles | Complete List | |
Roquan Smith
|
1. Roquan Smith, BAL | 82 |
| 2. Shaquille Leonard, IND | 79 | |
| 3. Kenneth Murray Jr, LAC | 67 | |
| 4. Denzel Perryman, LV | 66 | |
| 5. Devin White, TB | 64 | |
| Sacks | Complete List | |
Micah Parsons
|
1. Micah Parsons, DAL | 26 |
| 2. Maxx Crosby, SF | 25 | |
| 3. T.J. Watt, PIT | 23 | |
| 4. Joey Bosa, LAC | 19 | |
| 5. Nick Bosa, SF | 16 | |
| Interceptions | Complete List | |
Zyon McCollum
|
1. Zyon McCollum, TB | 16 |
| 2. Antoine Winfield Jr, TB | 15 | |
| 3. Israel Mukuamu, DAL | 13 | |
| 4. Minkah Fitzpatrick, PIT | 13 | |
| 5. Chris Westry, DAL | 11 | |