League Leaders - Offense
| Passing Yards | Complete List | |
Josh Allen
|
1. Josh Allen, BUF | 538 |
| 2. Shane Sharp, NE | 457 | |
| 3. Cam Meltzer, LV | 415 | |
| 4. Justin Herbert, LAC | 343 | |
| 5. Derek Carr, ATL | 337 | |
| Rushing Yards | Complete List | |
James Cook
|
1. James Cook, BUF | 356 |
| 2. Damien Harris, NE | 248 | |
| 3. Javonte Williams, DEN | 175 | |
| 4. Cordarrelle Patterson, KC | 141 | |
| 5. Alvin Kamara, NO | 132 | |
| Receiving Yards | Complete List | |
Calvin Ridley
|
1. Calvin Ridley, LV | 185 |
| 2. Albert Okwuegbunam, DEN | 182 | |
| 3. Hunter Henry, NE | 155 | |
| 4. Gabriel Davis, BUF | 140 | |
| 5. Khalil Shakir, BUF | 114 | |
League Leaders - Defense
| Tackles | Complete List | |
Jordan Poyer
|
1. Jordan Poyer, BUF | 9 |
| 2. Matt Milano, BUF | 8 | |
| 3. Micah Hyde, BUF | 7 | |
| 4. Tremaine Edmunds, BUF | 7 | |
| 5. Kenneth Murray Jr, LAC | 6 | |
| Sacks | Complete List | |
Matthew Judon
|
1. Matthew Judon, NE | 3 |
| 2. Bradley Chubb, DEN | 2 | |
| 3. Levi Onwuzurike, DET | 2 | |
| 4. Steven Scruggs, HOU | 2 | |
| 5. Terrel Bernard, BUF | 2 | |
| Interceptions | Complete List | |
Tre'Davious White
|
1. Tre'Davious White, BUF | 3 |
| 2. Bubba Bolden, NE | 2 | |
| 3. Ifeatu Melifonwu, DET | 2 | |
| 4. Casey Hayward Jr, KC | 2 | |
| 5. Greedy Williams, NE | 2 | |