League Leaders - Offense
| Passing Yards | Complete List | |
Trevor Lawrence
|
1. Trevor Lawrence, MIN | 4402 |
| 2. Kevin Hardy, PHI | 4003 | |
| 3. Rhett Taggart, SF | 3875 | |
| 4. Deshaun Watson, SEA | 3706 | |
| 5. Trey Lance, NO | 3524 | |
| Rushing Yards | Complete List | |
J.K. Dobbins
|
1. J.K. Dobbins, TB | 1514 |
| 2. Derrick Henry, LON | 1175 | |
| 3. Saquon Barkley, KC | 1080 | |
| 4. Josh Jacobs, LV | 1080 | |
| 5. Najee Harris, IND | 1076 | |
| Receiving Yards | Complete List | |
Ralph Holloman
|
1. Ralph Holloman, MIN | 1282 |
| 2. D.K. Metcalf, SF | 1269 | |
| 3. Ja'Marr Chase, PHI | 1224 | |
| 4. Jaylen Waddle, SEA | 1133 | |
| 5. Dillon House, MIN | 1129 | |
League Leaders - Defense
| Tackles | Complete List | |
Felix Johnson
|
1. Felix Johnson, WAS | 88 |
| 2. Sheldon Beckwith, ATL | 85 | |
| 3. Foyesade Oluokun, NO | 73 | |
| 4. Mykal Walker, PIT | 72 | |
| 5. Chauncey Richardson, MIA | 71 | |
| Sacks | Complete List | |
Josh Uche
|
1. Josh Uche, NYJ | 22 |
| 2. Baron Browning, NYG | 18 | |
| 3. Devin White, CIN | 15 | |
| 4. Trey Hendrickson, SEA | 14 | |
| 5. Micah Parsons, CHI | 12 | |
| Interceptions | Complete List | |
Cam Taylor-Britt
|
1. Cam Taylor-Britt, TB | 8 |
| 2. Tyson Campbell, MIN | 7 | |
| 3. Tariq Woolen, BAL | 7 | |
| 4. Eric Stokes, PHI | 6 | |
| 5. Paul Murray, KC | 6 | |