League Leaders - Offense
| Passing Yards | Complete List | |
Tua Tagovailoa
|
1. Tua Tagovailoa, GB | 1803 |
| 2. Sterling McAlister, WAS | 1616 | |
| 3. Patrick Mahomes, KC | 1580 | |
| 4. Justin Herbert, LAC | 1525 | |
| 5. Spencer Medlock, DEN | 1522 | |
| Rushing Yards | Complete List | |
D'Andre Swift
|
1. D'Andre Swift, GB | 491 |
| 2. Trey Benson, JAX | 477 | |
| 3. Bijan Robinson, ATL | 437 | |
| 4. Jonathon Brooks, MIN | 417 | |
| 5. De'Von Achane, MIA | 416 | |
| Receiving Yards | Complete List | |
Ja'Marr Chase
|
1. Ja'Marr Chase, CIN | 520 |
| 2. Justin Jefferson, MIN | 516 | |
| 3. Rome Odunze, CAR | 470 | |
| 4. CeeDee Lamb, DAL | 463 | |
| 5. Emmett Dunbar, DAL | 458 | |
League Leaders - Defense
| Tackles | Complete List | |
Dexter Jones
|
1. Dexter Jones, NYJ | 28 |
| 2. Cam Taylor-Britt, CIN | 28 | |
| 3. Jaquan Brisker, CHI | 27 | |
| 4. Danny Sweeting, NYJ | 27 | |
| 5. Jack Campbell, DET | 27 | |
| Sacks | Complete List | |
Rashaud Haden
|
1. Rashaud Haden, MIN | 7 |
| 2. Jeffery Simmons, TEN | 6 | |
| 3. Chad White, ARI | 6 | |
| 4. Felix Anudike-Uzomah, NE | 5 | |
| 5. Kenny Clark, GB | 5 | |
| Interceptions | Complete List | |
Nakobe Dean
|
1. Nakobe Dean, PHI | 5 |
| 2. Jordan Whitehead, NE | 5 | |
| 3. Jaycee Horn, CAR | 5 | |
| 4. Tremaine Edmunds, CHI | 5 | |
| 5. Bobby Lippett, GB | 4 | |