League Leaders - Offense
| Passing Yards | Complete List | |
Cesar Bailote
|
1. Cesar Bailote, NE | 4121 |
| 2. Kevin Kiernan, NO | 4023 | |
| 3. Tua Tagovailoa, MIA | 3970 | |
| 4. Joe Burrow, CIN | 3902 | |
| 5. Shawn Hardiman, HOU | 3859 | |
| Rushing Yards | Complete List | |
Miles Sanders
|
1. Miles Sanders, PHI | 1337 |
| 2. Cameron Kerr, NO | 1253 | |
| 3. Jose McDonald, WAS | 1192 | |
| 4. Jonathan Taylor, IND | 1139 | |
| 5. Tony Pollard, DAL | 1077 | |
| Receiving Yards | Complete List | |
Ben Lawson
|
1. Ben Lawson, LAR | 1379 |
| 2. Orlando Huff, NO | 1236 | |
| 3. Tyreek Hill, MIA | 1179 | |
| 4. Quinton Daniels, NO | 1168 | |
| 5. Pat Kramer, NYG | 1163 | |
League Leaders - Defense
| Tackles | Complete List | |
Krys Barnes
|
1. Krys Barnes, IND | 89 |
| 2. Jerome Baker, DEN | 86 | |
| 3. Clayton Starling, BAL | 83 | |
| 4. Myles Jack, PIT | 82 | |
| 5. Emmett Harrison, BUF | 81 | |
| Sacks | Complete List | |
Maxx Crosby
|
1. Maxx Crosby, LV | 16 |
| 2. Myles Garrett, CLE | 14 | |
| 3. Willie Gay, LAR | 14 | |
| 4. T.J. Watt, PIT | 14 | |
| 5. Nick Bosa, SF | 13 | |
| Interceptions | Complete List | |
Terrell Edmunds
|
1. Terrell Edmunds, DAL | 7 |
| 2. JC Jackson, LAC | 7 | |
| 3. Paulson Adebo, NO | 6 | |
| 4. Darrick Forrest, WAS | 6 | |
| 5. Asante Samuel Jr, LAC | 5 | |