League Leaders - Offense
| Passing Yards | Complete List | |
Seth Hughes
|
1. Seth Hughes, SEA | 5294 |
| 2. Cody Boss, HOU | 4716 | |
| 3. Patrick Mahomes, KC | 4674 | |
| 4. Malik Willis, ARI | 4597 | |
| 5. Chase Dugan, NYJ | 4595 | |
| Rushing Yards | Complete List | |
Brian Robinson Jr
|
1. Brian Robinson Jr, WAS | 2226 |
| 2. Kenneth Walker III, SEA | 1929 | |
| 3. Sean Miner, DET | 1912 | |
| 4. Dwayne Harris, MIA | 1862 | |
| 5. Isiah Pacheco, KC | 1766 | |
| Receiving Yards | Complete List | |
Danny Spencer
|
1. Danny Spencer, NYJ | 1781 |
| 2. Vernon Lacey, CHI | 1537 | |
| 3. Daniel Stanton, NE | 1524 | |
| 4. Travis Sears, LV | 1508 | |
| 5. Keron Bates, ARI | 1464 | |
League Leaders - Defense
| Tackles | Complete List | |
Myles Jack
|
1. Myles Jack, CAR | 76 |
| 2. Gill McClendon, KC | 59 | |
| 3. Bobby Okereke, BAL | 59 | |
| 4. Fred Warner, SF | 58 | |
| 5. Divine Deablo, CIN | 57 | |
| Sacks | Complete List | |
Micah Parsons
|
1. Micah Parsons, DAL | 16 |
| 2. Ben Snell, LAC | 15 | |
| 3. Morris Costanzo, BUF | 12 | |
| 4. Jon Tyson, DEN | 11 | |
| 5. Chase Young, WAS | 11 | |
| Interceptions | Complete List | |
Percy Butler
|
1. Percy Butler, WAS | 16 |
| 2. Lewis Cine, NYG | 15 | |
| 3. Marcell Morgan, NYJ | 14 | |
| 4. Trent McDuffie, KC | 12 | |
| 5. Jaycee Horn, NYG | 12 | |