League Leaders - Offense
| Passing Yards | Complete List | |
Russell Wilson
|
1. Russell Wilson, DEN | 2509 |
| 2. Matthew Stafford, LAR | 2377 | |
| 3. Deshaun Watson, CLE | 2358 | |
| 4. Dak Prescott, DAL | 2339 | |
| 5. Joe Burrow, CIN | 2289 | |
| Rushing Yards | Complete List | |
Nick Chubb
|
1. Nick Chubb, CLE | 889 |
| 2. Dameon Pierce, HOU | 834 | |
| 3. Jonathan Taylor, IND | 814 | |
| 4. Saquon Barkley, NYG | 749 | |
| 5. Joe Mixon, CIN | 743 | |
| Receiving Yards | Complete List | |
Terry McLaurin
|
1. Terry McLaurin, WAS | 776 |
| 2. Cooper Kupp, LAR | 750 | |
| 3. Stefon Diggs, BUF | 729 | |
| 4. Jerry Jeudy, DEN | 720 | |
| 5. Jaylen Waddle, MIA | 683 | |
League Leaders - Defense
| Tackles | Complete List | |
Marcus Samuels
|
1. Marcus Samuels, DET | 50 |
| 2. Patrick Queen, BAL | 49 | |
| 3. Eric Kendricks, MIN | 49 | |
| 4. Jeremiah Owusu-Koramoah, CLE | 47 | |
| 5. Fred Warner, SF | 45 | |
| Sacks | Complete List | |
Danielle Hunter
|
1. Danielle Hunter, MIN | 13 |
| 2. Myles Garrett, CLE | 11 | |
| 3. DeMarcus Lawrence, DAL | 7 | |
| 4. Nick Bosa, SF | 7 | |
| 5. Chase Young, WAS | 7 | |
| Interceptions | Complete List | |
Ashtyn Davis
|
1. Ashtyn Davis, NYJ | 6 |
| 2. Trevon Diggs, DAL | 6 | |
| 3. Trent McDuffie, KC | 5 | |
| 4. Micah Hyde, BUF | 5 | |
| 5. Jessie Bates III, CIN | 5 | |