League Leaders - Offense
| Passing Yards | Complete List | |
Trevor Lawrence
|
1. Trevor Lawrence, JAX | 317 |
| 2. Jalen Hurts, PHI | 298 | |
| 3. LJ Watkins, CAR | 272 | |
| 4. Shisui Uchiha, TB | 267 | |
| 5. DeAndre Payton, CHI | 198 | |
| Rushing Yards | Complete List | |
Christian McCaffrey
|
1. Christian McCaffrey, CAR | 87 |
| 2. Jose Dumaine, CAR | 46 | |
| 3. Jalen Hurts, PHI | 45 | |
| 4. Marcus Simms, MIN | 42 | |
| 5. Travis Etienne Jr, JAX | 36 | |
| Receiving Yards | Complete List | |
Mike Evans
|
1. Mike Evans, TB | 207 |
| 2. Emmanuel Routt, CAR | 128 | |
| 3. Cole Kmet, JAX | 111 | |
| 4. Angelo Murray, CHI | 106 | |
| 5. Jaxon Smith-Njigba, JAX | 103 | |
League Leaders - Defense
| Tackles | Complete List | |
Devin White
|
1. Devin White, TB | 6 |
| 2. Anthony Harper, TB | 6 | |
| 3. Roquan Smith, CHI | 5 | |
| 4. Antoine Winfield Jr, TB | 5 | |
| 5. Carlton Davis III, TB | 5 | |
| Sacks | Complete List | |
Roquan Smith
|
1. Roquan Smith, CHI | 2 |
| 2. Amare Barno, TB | 2 | |
| 3. Cole Holcomb, MIN | 2 | |
| 4. Danielle Hunter, MIN | 2 | |
| 5. Shaquil Barrett, TB | 2 | |
| Interceptions | Complete List | |
Kamren Curl
|
1. Kamren Curl, MIN | 3 |
| 2. Lewis Cine, MIN | 2 | |
| 3. Cameron Dantzler, MIN | 2 | |
| 4. Jaylon Johnson, CHI | 1 | |
| 5. Dane Cruikshank, JAX | 1 | |