League Leaders - Offense
| Passing Yards | Complete List | |
Josh Allen
|
1. Josh Allen, DET | 2035 |
| 2. C.J. Stroud, HOU | 2035 | |
| 3. Mike Black, NO | 1796 | |
| 4. Trevor Lawrence, JAX | 1722 | |
| 5. Nolan Schroeder, NYG | 1617 | |
| Rushing Yards | Complete List | |
Nathan Barkley
|
1. Nathan Barkley, DEN | 551 |
| 2. Kenneth Walker III, SEA | 546 | |
| 3. Jonathan Taylor, IND | 528 | |
| 4. Bijan Robinson, ATL | 472 | |
| 5. De'Von Achane, WAS | 433 | |
| Receiving Yards | Complete List | |
Nico Collins
|
1. Nico Collins, HOU | 762 |
| 2. Tyler Harrell, NYJ | 711 | |
| 3. Rob Sanborn, NE | 663 | |
| 4. Chuck Childers, SF | 545 | |
| 5. Justin Jefferson, MIN | 526 | |
League Leaders - Defense
| Tackles | Complete List | |
Don Macklin
|
1. Don Macklin, ATL | 26 |
| 2. Darrick Forrest, WAS | 22 | |
| 3. Isaiah Simmons, DAL | 21 | |
| 4. Daniel Scott, TB | 19 | |
| 5. Jarrick Bernard-Converse, ATL | 18 | |
| Sacks | Complete List | |
Drew Sanders
|
1. Drew Sanders, DEN | 7 |
| 2. Rocky Johnson, CLE | 7 | |
| 3. Kwity Paye, IND | 6 | |
| 4. Myles Garrett, CLE | 5 | |
| 5. Jaelan Phillips, DEN | 5 | |
| Interceptions | Complete List | |
Deonte Banks
|
1. Deonte Banks, DET | 9 |
| 2. Earl Woodley, NYG | 5 | |
| 3. Terrion Arnold, DET | 5 | |
| 4. Leo Chenal, SF | 5 | |
| 5. Jack Campbell, SF | 4 | |