League Leaders - Offense
| Passing Yards | Complete List | |
Kevin Kearse
|
1. Kevin Kearse, CHI | 3887 |
| 2. Tua Tagovailoa, TEN | 3830 | |
| 3. Erick Batten, DAL | 3805 | |
| 4. Trevor Lawrence, JAX | 3679 | |
| 5. A.J. Johnson, MIN | 3506 | |
| Rushing Yards | Complete List | |
Breece Hall
|
1. Breece Hall, CHI | 1808 |
| 2. Bijan Robinson, ATL | 1527 | |
| 3. Morgan Jordan, LAR | 1261 | |
| 4. Christian McCaffrey, SF | 1164 | |
| 5. Josh Jacobs, LV | 1157 | |
| Receiving Yards | Complete List | |
Chris Olave
|
1. Chris Olave, CHI | 1635 |
| 2. Puka Nacua, LAR | 1516 | |
| 3. CeeDee Lamb, DAL | 1366 | |
| 4. Justin Jefferson, MIN | 1250 | |
| 5. Tyreek Hill, LV | 1118 | |
League Leaders - Defense
| Tackles | Complete List | |
Brian Sharp
|
1. Brian Sharp, IND | 89 |
| 2. Roquan Smith, BAL | 86 | |
| 3. Channing Tindall, MIA | 84 | |
| 4. Patrick Queen, CIN | 84 | |
| 5. Jeremiah Owusu-Koramoah, CLE | 82 | |
| Sacks | Complete List | |
Micah Parsons
|
1. Micah Parsons, DAL | 18 |
| 2. Maxx Crosby, SF | 16 | |
| 3. Haason Reddick, LAR | 15 | |
| 4. Brian Burns, ARI | 13 | |
| 5. Myles Murphy, CIN | 12 | |
| Interceptions | Complete List | |
Chidobe Awuzie
|
1. Chidobe Awuzie, SF | 10 |
| 2. Tyrique Stevenson, CHI | 8 | |
| 3. Jaylon Johnson, LAR | 7 | |
| 4. Marshon Lattimore, CHI | 7 | |
| 5. Ryan Neal, SF | 4 | |