League Leaders - Offense
| Passing Yards | Complete List | |
Zach Wilson
|
1. Zach Wilson, NYJ | 1288 |
| 2. Mac Jones, NE | 948 | |
| 3. Lamar Jackson, BAL | 942 | |
| 4. Joe Burrow, CIN | 796 | |
| 5. Desmond Ridder, ATL | 733 | |
| Rushing Yards | Complete List | |
Dalvin Cook
|
1. Dalvin Cook, MIN | 336 |
| 2. Christian McCaffrey, CAR | 333 | |
| 3. Breece Hall, ARI | 211 | |
| 4. Elijah Mitchell, SF | 196 | |
| 5. Ezekiel Elliott, DAL | 193 | |
| Receiving Yards | Complete List | |
Diontae Johnson
|
1. Diontae Johnson, PIT | 395 |
| 2. Cooper Kupp, LAR | 374 | |
| 3. Elijah Moore, NYJ | 368 | |
| 4. Garrett Wilson, NYJ | 341 | |
| 5. Marquise Goodwin, BAL | 331 | |
League Leaders - Defense
| Tackles | Complete List | |
Nick Scott
|
1. Nick Scott, SEA | 19 |
| 2. Julian Love, SEA | 18 | |
| 3. Nick Cross, IND | 18 | |
| 4. Jonathan Jones, NE | 17 | |
| 5. Troy Andersen, ATL | 15 | |
| Sacks | Complete List | |
Micah Parsons
|
1. Micah Parsons, DAL | 6 |
| 2. Khalil Mack, LAC | 4 | |
| 3. Von Miller, BUF | 4 | |
| 4. Robert Quinn, CHI | 4 | |
| 5. Alex Highsmith, PIT | 4 | |
| Interceptions | Complete List | |
Byron Murphy Jr
|
1. Byron Murphy Jr, NYJ | 5 |
| 2. JT Woods, NYJ | 5 | |
| 3. Adrian Phillips, NE | 4 | |
| 4. Trevon Diggs, DAL | 3 | |
| 5. Tycen Anderson, CIN | 3 | |