League Leaders - Offense
| Passing Yards | Complete List | |
Baker Mayfield
|
1. Baker Mayfield, TB | 5273 |
| 2. Desmond Ridder, ATL | 4917 | |
| 3. Justin Herbert, LAC | 4823 | |
| 4. Hendon Hoker, DET | 4750 | |
| 5. Lamar Jackson, BAL | 4690 | |
| Rushing Yards | Complete List | |
Qujuan Walker
|
1. Qujuan Walker, CHI | 1990 |
| 2. Derrick Henry, TEN | 1506 | |
| 3. J.K. Dobbins, BAL | 1474 | |
| 4. Devon Achane, MIA | 1420 | |
| 5. Jonathan Taylor, IND | 1361 | |
| Receiving Yards | Complete List | |
Irving Petersen
|
1. Irving Petersen, CHI | 1998 |
| 2. Jameson Williams, DET | 1838 | |
| 3. Justin Jefferson, MIN | 1529 | |
| 4. Deebo Samuel, SF | 1503 | |
| 5. Chris Godwin, TB | 1468 | |
League Leaders - Defense
| Tackles | Complete List | |
Pete Werner
|
1. Pete Werner, NO | 133 |
| 2. Fred Warner, SF | 127 | |
| 3. Cole Holcomb, PIT | 119 | |
| 4. Jayon Brown, TEN | 118 | |
| 5. Foyesade Oluokun, JAX | 112 | |
| Sacks | Complete List | |
Joey Bosa
|
1. Joey Bosa, LAC | 20 |
| 2. Maxx Crosby, LV | 19 | |
| 3. Jaimu Bolaji Ojulari, ARI | 18 | |
| 4. Will Anderson Jr., HOU | 18 | |
| 5. James Houston IV, DET | 18 | |
| Interceptions | Complete List | |
Eddie Jackson
|
1. Eddie Jackson, CHI | 8 |
| 2. Darius Rush, CHI | 8 | |
| 3. Trevon Diggs, DAL | 8 | |
| 4. Jayron Kearse, DAL | 7 | |
| 5. DeWayne Petersen, CHI | 7 | |