League Leaders - Offense
| Passing Yards | Complete List | |
Patrick Mahomes
|
1. Patrick Mahomes, KC | 5016 |
| 2. Jayden Daniels, WAS | 4830 | |
| 3. Lamar Jackson, BAL | 4552 | |
| 4. Trevor Lawrence, JAX | 4533 | |
| 5. Brett Woody, SEA | 4298 | |
| Rushing Yards | Complete List | |
Monty Wolff
|
1. Monty Wolff, NYG | 1343 |
| 2. Breece Hall, NYJ | 1164 | |
| 3. Damien Bailey, NE | 1069 | |
| 4. Isiah Pacheco, KC | 1034 | |
| 5. Alvin Kamara, NO | 957 | |
| Receiving Yards | Complete List | |
Darren James
|
1. Darren James, ATL | 1844 |
| 2. Randy Moss, NE | 1802 | |
| 3. Xavier Worthy, KC | 1627 | |
| 4. Santana Moss, WAS | 1558 | |
| 5. Benjamin Anthony, KC | 1278 | |
League Leaders - Defense
| Tackles | Complete List | |
Matt McGraw
|
1. Matt McGraw, ARI | 90 |
| 2. Germaine Pratt, CIN | 90 | |
| 3. Divine Deablo, LV | 73 | |
| 4. Nate Dickerson, DEN | 73 | |
| 5. William Reece, IND | 72 | |
| Sacks | Complete List | |
Ty Palmer
|
1. Ty Palmer, JAX | 17 |
| 2. T.J. Watt, PIT | 13 | |
| 3. Derrick Thomas, KC | 12 | |
| 4. Josh Hines-Allen, JAX | 11 | |
| 5. Jonah Elliss, DEN | 11 | |
| Interceptions | Complete List | |
Ty Law
|
1. Ty Law, KC | 11 |
| 2. Johnny Groves, CAR | 11 | |
| 3. Roquan Smith, BAL | 10 | |
| 4. Spencer Amos, WAS | 8 | |
| 5. Sean Taylor, WAS | 8 | |