League Leaders - Offense
| Passing Yards | Complete List | |
Brock Purdy
|
1. Brock Purdy, RIO | 5152 |
| 2. Alani Washington, CLS | 4761 | |
| 3. Joe Burrow, ORL | 4657 | |
| 4. Anthony Richardson, SA | 3965 | |
| 5. Malik Willis, BA | 3825 | |
| Rushing Yards | Complete List | |
Bully McCaffrey
|
1. Bully McCaffrey, CAR | 1560 |
| 2. Jonathan Taylor, SA | 1501 | |
| 3. Eddie George, BA | 1432 | |
| 4. Saquon Barkley, MIN | 1278 | |
| 5. Xavier Jackson, NE | 1272 | |
| Receiving Yards | Complete List | |
Brandon Aiyuk
|
1. Brandon Aiyuk, RIO | 1766 |
| 2. Puka Nacua, AUS | 1570 | |
| 3. Ja'Marr Chase, ORL | 1403 | |
| 4. T.J. Newberry, NE | 1379 | |
| 5. Marlon Warrick, SDG | 1368 | |
League Leaders - Defense
| Tackles | Complete List | |
Talanoa Hufanga
|
1. Talanoa Hufanga, RIO | 55 |
| 2. Patrick Queen, BAL | 54 | |
| 3. Foyesade Oluokun, JAX | 52 | |
| 4. Nick Cross, SA | 52 | |
| 5. Jack Campbell, DET | 51 | |
| Sacks | Complete List | |
Chase Young
|
1. Chase Young, SA | 18 |
| 2. Danielle Hunter, BA | 12 | |
| 3. Maxx Crosby, CHO | 12 | |
| 4. Myles Garrett, KC | 11 | |
| 5. Nick Bosa, RIO | 10 | |
| Interceptions | Complete List | |
Nick Cross
|
1. Nick Cross, SA | 18 |
| 2. Eric Berry, KC | 15 | |
| 3. Eddie Greenfield, SA | 13 | |
| 4. Randall Royals, CLS | 11 | |
| 5. Grant Delpit, CLE | 10 | |