League Leaders - Offense
| Passing Yards | Complete List | |
Sam Howell
|
1. Sam Howell, BUF | 1860 |
| 2. Jalen Hurts, PHI | 1567 | |
| 3. Will Levis, NYG | 1566 | |
| 4. Patrick Mahomes, KC | 1521 | |
| 5. Trey Lance, NE | 1387 | |
| Rushing Yards | Complete List | |
Najee Harris
|
1. Najee Harris, PIT | 639 |
| 2. Brian Robinson Jr, WAS | 588 | |
| 3. Keaton Mitchell, BAL | 525 | |
| 4. I EAT GROCERIES DEMI, LAC | 486 | |
| 5. Miles Sanders, ARI | 456 | |
| Receiving Yards | Complete List | |
Gregory Day
|
1. Gregory Day, ATL | 573 |
| 2. Tracey Hobbs, BUF | 564 | |
| 3. A.J. Brown, PHI | 518 | |
| 4. Ja'Marr Chase, CLE | 474 | |
| 5. Hines Ward II, CIN | 471 | |
League Leaders - Defense
| Tackles | Complete List | |
Marte Mapu
|
1. Marte Mapu, JAX | 31 |
| 2. Aaron Jones, HOU | 31 | |
| 3. Donovan Rolle, MIN | 30 | |
| 4. Germaine Pratt, HOU | 29 | |
| 5. Benjamin St-Juste, NYJ | 28 | |
| Sacks | Complete List | |
Joey Bosa
|
1. Joey Bosa, HOU | 7 |
| 2. Rashan Gary, GB | 6 | |
| 3. Michael Hall Jr., SEA | 6 | |
| 4. Matt Dixon, IND | 6 | |
| 5. Chase Young, WAS | 6 | |
| Interceptions | Complete List | |
Richard Sherman Jr Demi
|
1. Richard Sherman Jr Demi, LAC | 5 |
| 2. Demetrious Burnett, BAL | 4 | |
| 3. Twenty-One Savage, CHI | 4 | |
| 4. Kamren Curl, LAR | 4 | |
| 5. Justin Reid, ARI | 4 | |