League Leaders - Offense
| Passing Yards | Complete List | |
Shaddrick Powers
|
1. Shaddrick Powers, PHI | 7751 |
| 2. Jaden Rashada, KC | 7726 | |
| 3. Anthony Richardson, IND | 6971 | |
| 4. T.J. Homan, PIT | 5746 | |
| 5. Blake Boyle, DEN | 5723 | |
| Rushing Yards | Complete List | |
Tawee Walker
|
1. Tawee Walker, IND | 3099 |
| 2. Kenneth Walker III, NYG | 1527 | |
| 3. Carlos Greenberry, PIT | 1520 | |
| 4. Josh Jacobs, LV | 1497 | |
| 5. Najee Harris, GB | 1429 | |
| Receiving Yards | Complete List | |
Qua'leek Samuel
|
1. Qua'leek Samuel, PHI | 2889 |
| 2. Jaylen Waddle, SF | 2728 | |
| 3. Roman Middleton, KC | 2559 | |
| 4. Vinny Anthony II, IND | 1793 | |
| 5. Gary Sheppard, PIT | 1702 | |
League Leaders - Defense
| Tackles | Complete List | |
Owen Pappoe
|
1. Owen Pappoe, IND | 173 |
| 2. DeMarvion Overshown, ARI | 120 | |
| 3. Joey Flowers, SEA | 115 | |
| 4. Tremaine Edmunds, DEN | 112 | |
| 5. Divine Deablo, LV | 110 | |
| Sacks | Complete List | |
Kayvon Thibodeaux
|
1. Kayvon Thibodeaux, IND | 26 |
| 2. Maxx Crosby, DAL | 25 | |
| 3. Travon Walker, IND | 24 | |
| 4. Juan Payne, IND | 24 | |
| 5. Quinton Canidate, KC | 23 | |
| Interceptions | Complete List | |
Patrick Surtain II
|
1. Patrick Surtain II, PHI | 13 |
| 2. Jaycee Horn, IND | 12 | |
| 3. Julius Brents, KC | 10 | |
| 4. Sauce Gardner, IND | 10 | |
| 5. Scooby Williams, KC | 9 | |