League Leaders - Offense
| Passing Yards | Complete List | |
Joe Burrow
|
1. Joe Burrow, CIN | 3359 |
| 2. Dak Prescott, SF | 3352 | |
| 3. Michael Giles, NYG | 3167 | |
| 4. Justin Fields, LV | 3029 | |
| 5. Sam Young, TB | 3006 | |
| Rushing Yards | Complete List | |
Braelon Allen
|
1. Braelon Allen, TB | 1113 |
| 2. Christian McCaffrey, NYJ | 1046 | |
| 3. Joe Mixon, PIT | 925 | |
| 4. LaDainian Tomlinson, MIA | 904 | |
| 5. Jonathan Taylor, IND | 777 | |
| Receiving Yards | Complete List | |
Chad Ochocinco
|
1. Chad Ochocinco, LV | 1328 |
| 2. Marquise Brown, CIN | 1132 | |
| 3. Tyreek Hill, NYG | 1131 | |
| 4. George Kittle, SF | 1082 | |
| 5. Denzel Boston, TB | 1024 | |
League Leaders - Defense
| Tackles | Complete List | |
David Long Jr
|
1. David Long Jr, SEA | 60 |
| 2. Kenneth Murray Jr, TB | 58 | |
| 3. Divine Deablo, IND | 57 | |
| 4. Zach Cunningham, NYJ | 57 | |
| 5. Myles Jack, SEA | 57 | |
| Sacks | Complete List | |
James Harrison
|
1. James Harrison, TB | 14 |
| 2. Brian Burns, CAR | 14 | |
| 3. Trey Hendrickson, SF | 13 | |
| 4. Chase Young, CIN | 13 | |
| 5. T.J. Watt, DET | 12 | |
| Interceptions | Complete List | |
Jalen Ramsey
|
1. Jalen Ramsey, LV | 8 |
| 2. Jaycee Horn, TB | 6 | |
| 3. Brian Dawkins, CIN | 6 | |
| 4. Tremaine Edmunds, CIN | 5 | |
| 5. Patrick Surtain II, DEN | 5 | |