League Leaders - Offense
| Passing Yards | Complete List | |
Malik Willis
|
1. Malik Willis, TEN | 1460 |
| 2. Deshaun Watson, CLE | 1366 | |
| 3. Josh Allen, BUF | 1344 | |
| 4. Chad Harris, CHI | 1332 | |
| 5. Jared Goff, DET | 1295 | |
| Rushing Yards | Complete List | |
Miles Sanders
|
1. Miles Sanders, PHI | 779 |
| 2. Jarvis Peters, MIA | 713 | |
| 3. Dalvin Cook, MIN | 596 | |
| 4. Josh Jacobs, LV | 582 | |
| 5. Breece Hall, NYJ | 534 | |
| Receiving Yards | Complete List | |
Larry Carroll
|
1. Larry Carroll, TEN | 629 |
| 2. Jerry Holliday, NYG | 600 | |
| 3. Tre Lewis, JAX | 572 | |
| 4. Odell Beckham Jr, NO | 531 | |
| 5. Jameson Williams, DET | 514 | |
League Leaders - Defense
| Tackles | Complete List | |
Dre Greenlaw
|
1. Dre Greenlaw, NYJ | 25 |
| 2. Jamin Davis, WAS | 24 | |
| 3. Lynn Burris, CAR | 21 | |
| 4. Kendall Fuller, WAS | 21 | |
| 5. Jeremiah Owusu-Koramoah, CLE | 20 | |
| Sacks | Complete List | |
Dexter Lawrence II
|
1. Dexter Lawrence II, NYG | 7 |
| 2. Danielle Hunter, BUF | 6 | |
| 3. Yannick Ngakoue, IND | 6 | |
| 4. Drake Jackson, SF | 6 | |
| 5. Haason Reddick, PHI | 5 | |
| Interceptions | Complete List | |
Nick Mayle
|
1. Nick Mayle, MIA | 7 |
| 2. Kevin Daniels, PHI | 7 | |
| 3. Jalen Thompson, ARI | 6 | |
| 4. Justin Williams, GB | 6 | |
| 5. Trevon Moehrig, LV | 6 | |