League Leaders - Offense
| Passing Yards | Complete List | |
Dan Marino Jr
|
1. Dan Marino Jr, DAL | 5241 |
| 2. Patrick Mahomes, KC | 5147 | |
| 3. Justin Herbert, LAC | 5132 | |
| 4. Bryce Young, CAR | 4845 | |
| 5. Leon Hayes, PIT | 4681 | |
| Rushing Yards | Complete List | |
Saquon Barkley
|
1. Saquon Barkley, NYG | 1567 |
| 2. Kenneth Walker III, SEA | 1352 | |
| 3. Josh Jacobs, LAR | 1305 | |
| 4. Jonathan Taylor, IND | 1298 | |
| 5. Israel Abanikanda, NYJ | 1249 | |
| Receiving Yards | Complete List | |
CeeDee Lamb
|
1. CeeDee Lamb, DAL | 1599 |
| 2. Terry McLaurin, LAC | 1418 | |
| 3. Jamie Randolph, DAL | 1388 | |
| 4. Chester Dobbins, PIT | 1380 | |
| 5. Jameson Williams, BAL | 1342 | |
League Leaders - Defense
| Tackles | Complete List | |
Benjamin St-Juste
|
1. Benjamin St-Juste, WAS | 89 |
| 2. Roquan Smith, BAL | 81 | |
| 3. Fred Warner, SF | 77 | |
| 4. Denzel Ward, CLE | 72 | |
| 5. Chris McAlister, BAL | 71 | |
| Sacks | Complete List | |
Myles Garrett
|
1. Myles Garrett, CLE | 16 |
| 2. Micah Parsons, DAL | 13 | |
| 3. Joey Bosa, LAC | 13 | |
| 4. T.J. Watt, CAR | 12 | |
| 5. Chase Young, LAC | 11 | |
| Interceptions | Complete List | |
Craig Gardener
|
1. Craig Gardener, DEN | 10 |
| 2. Trevon Diggs, DAL | 10 | |
| 3. Isaiah Simmons, NYG | 9 | |
| 4. Kelvin Joseph, DAL | 9 | |
| 5. Deonte Banks, NYG | 9 | |