League Leaders - Offense
| Passing Yards | Complete List | |
Patrick Mahomes
|
1. Patrick Mahomes, KC | 4485 |
| 2. Zach Wilson, NYJ | 3485 | |
| 3. Davis Mills, HOU | 3462 | |
| 4. Jameis Winston, NO | 3461 | |
| 5. Justin Fields, CHI | 3413 | |
| Rushing Yards | Complete List | |
Aaron Jones
|
1. Aaron Jones, GB | 1412 |
| 2. Ezekiel Elliott, DAL | 1333 | |
| 3. Christian McCaffrey, SF | 1332 | |
| 4. Alvin Kamara, NO | 1306 | |
| 5. Jonathan Taylor, IND | 1273 | |
| Receiving Yards | Complete List | |
Drake London
|
1. Drake London, KC | 1514 |
| 2. Kyle Pitts, ATL | 1314 | |
| 3. Chris Godwin, TB | 1293 | |
| 4. Kadarius Toney, KC | 1286 | |
| 5. Courtland Sutton, DEN | 1222 | |
League Leaders - Defense
| Tackles | Complete List | |
Tremaine Edmunds
|
1. Tremaine Edmunds, BUF | 65 |
| 2. Shaq Thompson, CAR | 59 | |
| 3. De'Vondre Campbell, GB | 54 | |
| 4. Bobby Wagner, LAR | 51 | |
| 5. Landon Collins, NYG | 50 | |
| Sacks | Complete List | |
Maxx Crosby
|
1. Maxx Crosby, LV | 19 |
| 2. Nick Bosa, SF | 14 | |
| 3. Shaquil Barrett, TB | 14 | |
| 4. Myles Garrett, CLE | 12 | |
| 5. Brian Burns, CAR | 12 | |
| Interceptions | Complete List | |
Marcus Williams
|
1. Marcus Williams, BAL | 12 |
| 2. Justin Reid, KC | 11 | |
| 3. Derwin James Jr, LAC | 11 | |
| 4. Marcus Peters, BAL | 10 | |
| 5. Eddie Jackson, CHI | 10 | |