League Leaders - Offense
| Passing Yards | Complete List | |
Trevor Lawrence
|
1. Trevor Lawrence, JAX | 5197 |
| 2. Deshaun Watson, CLE | 3481 | |
| 3. Joe Burrow, CIN | 3327 | |
| 4. Will Levis, DET | 3086 | |
| 5. Caleb Williams, LV | 3035 | |
| Rushing Yards | Complete List | |
TreVeyon Henderson
|
1. TreVeyon Henderson, JAX | 1141 |
| 2. Lovasea Carroll, CIN | 740 | |
| 3. Blake Corum, MIA | 616 | |
| 4. Trevion Cooley, GB | 588 | |
| 5. Javonte Williams, DEN | 571 | |
| Receiving Yards | Complete List | |
JoJo Earle
|
1. JoJo Earle, JAX | 2144 |
| 2. Marquez Valdes-Scantling, JAX | 1712 | |
| 3. Anthony Schwartz, CLE | 1228 | |
| 4. Jameson Williams, DET | 1108 | |
| 5. Ja'Marr Chase, CIN | 1068 | |
League Leaders - Defense
| Tackles | Complete List | |
Kelvin Joseph
|
1. Kelvin Joseph, JAX | 29 |
| 2. Daxton Hill, CIN | 29 | |
| 3. Cam Taylor-Britt, CIN | 25 | |
| 4. Tyson Campbell, JAX | 24 | |
| 5. Jerome Baker, MIA | 21 | |
| Sacks | Complete List | |
Aaron Donald
|
1. Aaron Donald, LV | 11 |
| 2. Brian Burns, DET | 8 | |
| 3. Lukas Van Ness, JAX | 7 | |
| 4. Myles Garrett, CLE | 7 | |
| 5. Blake Cashman, JAX | 7 | |
| Interceptions | Complete List | |
|
Kelvin Joseph
|
1. Kelvin Joseph, JAX | 13 |
| 2. Patrick Surtain II, DEN | 12 | |
| 3. Eli Ricks, JAX | 10 | |
| 4. Justin Simmons, DEN | 8 | |
| 5. Jaden Mangham, CIN | 8 | |