League Leaders - Offense
| Passing Yards | Complete List | |
J.J. McCarthy
|
1. J.J. McCarthy, MIN | 4803 |
| 2. Josh Allen, BUF | 4724 | |
| 3. Bryce Young, CAR | 4648 | |
| 4. Cam Ward, TEN | 4482 | |
| 5. Jared Goff, DET | 4474 | |
| Rushing Yards | Complete List | |
Derrick Henry
|
1. Derrick Henry, BAL | 1273 |
| 2. Jahmyr Gibbs, DET | 1247 | |
| 3. Jaydon Blue, DAL | 1176 | |
| 4. Trey Benson, ARI | 1152 | |
| 5. Kyren Williams, LAR | 1114 | |
| Receiving Yards | Complete List | |
Justin Jefferson
|
1. Justin Jefferson, MIN | 1989 |
| 2. Josh Downs, IND | 1404 | |
| 3. Amon-Ra St. Brown, DET | 1338 | |
| 4. CeeDee Lamb, DAL | 1336 | |
| 5. Tetairoa McMillan, CAR | 1314 | |
League Leaders - Defense
| Tackles | Complete List | |
Zack Baun
|
1. Zack Baun, PHI | 106 |
| 2. Devin Lloyd, JAX | 103 | |
| 3. Cody Barton, TEN | 92 | |
| 4. Dezz Ricks, ATL | 88 | |
| 5. Omar Speights, LAR | 87 | |
| Sacks | Complete List | |
Aidan Hutchinson
|
1. Aidan Hutchinson, DET | 18 |
| 2. Micah Parsons, DAL | 17 | |
| 3. Vernon Broughton, NO | 16 | |
| 4. T.J. Watt, PIT | 15 | |
| 5. Zaven Collins, ARI | 14 | |
| Interceptions | Complete List | |
Amani Hooker
|
1. Amani Hooker, TB | 8 |
| 2. Denzel Ward, CLE | 7 | |
| 3. Charvarius Ward, IND | 6 | |
| 4. Kenny Moore II, IND | 5 | |
| 5. Antoine Winfield Jr, TB | 5 | |