League Leaders - Offense
| Passing Yards | Complete List | |
Jayden Daniels
|
1. Jayden Daniels, TEN | 7402 |
| 2. Lamar Jackson, MEX | 6751 | |
| 3. Joe Milton III, SF | 6346 | |
| 4. Trey Lance, CAR | 5717 | |
| 5. Justin Herbert, LAC | 5475 | |
| Rushing Yards | Complete List | |
Rachaad White
|
1. Rachaad White, TB | 1875 |
| 2. Chase Brown, CIN | 1861 | |
| 3. DeMarco Brockers, IND | 1859 | |
| 4. Travis Etienne Jr, CHI | 1788 | |
| 5. Jahmyr Gibbs, DET | 1743 | |
| Receiving Yards | Complete List | |
Jeremiah Hodges
|
1. Jeremiah Hodges, TEN | 4472 |
| 2. Carlos Crockett, CIN | 2679 | |
| 3. Justice Nirobe, LAC | 2621 | |
| 4. Jaylen Waddle, SF | 2363 | |
| 5. De'Von Achane, MEX | 2212 | |
League Leaders - Defense
| Tackles | Complete List | |
Nick Bolton
|
1. Nick Bolton, KC | 82 |
| 2. Leo Chenal, KC | 81 | |
| 3. Dorian Williams, MIN | 76 | |
| 4. George Golston, DET | 74 | |
| 5. Ra's al Ghul, SF | 71 | |
| Sacks | Complete List | |
Terrelle Boothe
|
1. Terrelle Boothe, CIN | 16 |
| 2. T.J. Watt, PIT | 15 | |
| 3. Dallas Turner, MIN | 15 | |
| 4. Daryl Porter, ARI | 14 | |
| 5. Manny Holmes, SF | 14 | |
| Interceptions | Complete List | |
Max Melton
|
1. Max Melton, MEX | 15 |
| 2. Klay Peterson, TEN | 14 | |
| 3. Tyrique Stevenson, CHI | 12 | |
| 4. Marlon Humphrey, DAL | 12 | |
| 5. Jalen Ramsey, NYJ | 11 | |