League Leaders - Offense
| Passing Yards | Complete List | |
Lamar Jackson
|
1. Lamar Jackson, BAL | 1051 |
| 2. CJ Stroud, NE | 918 | |
| 3. Justin Herbert, LAC | 902 | |
| 4. Baker Mayfield, PIT | 868 | |
| 5. Jalen Hurts, PHI | 770 | |
| Rushing Yards | Complete List | |
Derrick Henry
|
1. Derrick Henry, TEN | 445 |
| 2. Travis Etienne Jr, JAX | 344 | |
| 3. Jonathan Taylor, IND | 324 | |
| 4. Christian McCaffrey, CHI | 267 | |
| 5. James Cook, BUF | 240 | |
| Receiving Yards | Complete List | |
Josh Downs
|
1. Josh Downs, DET | 395 |
| 2. Rashod Bateman, BAL | 355 | |
| 3. Diontae Johnson, PIT | 319 | |
| 4. Calvin Ridley, JAX | 304 | |
| 5. Keenan Allen, LAC | 297 | |
League Leaders - Defense
| Tackles | Complete List | |
Anthony Barr
|
1. Anthony Barr, DAL | 21 |
| 2. Myles Jack, PIT | 19 | |
| 3. Terrell Edmunds, PIT | 14 | |
| 4. Kenneth Murray Jr, LAC | 14 | |
| 5. Andrew Van Ginkel, MIA | 14 | |
| Sacks | Complete List | |
Aidan Hutchinson
|
1. Aidan Hutchinson, DET | 5 |
| 2. Harold Landry III, TEN | 4 | |
| 3. Von Miller, BUF | 3 | |
| 4. Yannick Ngakoue, IND | 3 | |
| 5. Brian Burns, CAR | 3 | |
| Interceptions | Complete List | |
Nasir Adderley
|
1. Nasir Adderley, TB | 5 |
| 2. Andrew Booth Jr, MIN | 4 | |
| 3. Jalen Thompson, ARI | 4 | |
| 4. Patrick Surtain II, DEN | 3 | |
| 5. Jaylon Johnson, CHI | 3 | |