League Leaders - Offense
| Passing Yards | Complete List | |
Patrick Mahomes
|
1. Patrick Mahomes, HST | 4350 |
| 2. Brock Purdy, ANC | 4188 | |
| 3. Bryce Young, CAR | 3650 | |
| 4. Dak Prescott, DAL | 3460 | |
| 5. Baker Mayfield, TB | 3304 | |
| Rushing Yards | Complete List | |
Devin Singletary
|
1. Devin Singletary, NYG | 2115 |
| 2. Blake Corum, LAR | 1485 | |
| 3. Joe Mixon, HOU | 1424 | |
| 4. Saquon Barkley, PHI | 1276 | |
| 5. Austin Ekeler, WAS | 1253 | |
| Receiving Yards | Complete List | |
Travis Kelce
|
1. Travis Kelce, HST | 1394 |
| 2. CeeDee Lamb, DAL | 1343 | |
| 3. Xavier Worthy, HST | 1219 | |
| 4. Ricky Pearsall, ANC | 1215 | |
| 5. Xavier Leggette, CAR | 1160 | |
League Leaders - Defense
| Tackles | Complete List | |
Divine Deablo
|
1. Divine Deablo, LV | 79 |
| 2. Troy Andersen, ATL | 75 | |
| 3. Markquese Bell, DAL | 71 | |
| 4. Denzel Perryman, LAC | 67 | |
| 5. Owen Pappoe, ARI | 63 | |
| Sacks | Complete List | |
Travon Walker
|
1. Travon Walker, JAX | 17 |
| 2. Micah Parsons, DAL | 15 | |
| 3. Josh Allen, JAX | 12 | |
| 4. Matthew Judon, NE | 11 | |
| 5. Nick Bosa, ANC | 11 | |
| Interceptions | Complete List | |
Fred Warner
|
1. Fred Warner, ANC | 15 |
| 2. Nolan Turner, TB | 13 | |
| 3. Kyle Hamilton, OAK | 11 | |
| 4. Roquan Smith, OAK | 10 | |
| 5. Chamarri Conner, HST | 8 | |