League Leaders - Offense
| Passing Yards | Complete List | |
Patrick Mahomes
|
1. Patrick Mahomes, NE | 3233 |
| 2. Joe Burrow, CIN | 3143 | |
| 3. Jimmy Garoppolo, LV | 2953 | |
| 4. Will Levis, TB | 2947 | |
| 5. Kyler Murray, ARI | 2791 | |
| Rushing Yards | Complete List | |
Jonathan Taylor
|
1. Jonathan Taylor, IND | 1160 |
| 2. Derrick Henry, TEN | 1073 | |
| 3. Josh Jacobs, LV | 1034 | |
| 4. Joe Mixon, CIN | 892 | |
| 5. Najee Harris, PIT | 822 | |
| Receiving Yards | Complete List | |
Justin Jefferson
|
1. Justin Jefferson, NE | 1157 |
| 2. Mike Evans, TB | 937 | |
| 3. Cooper Kupp, LAR | 929 | |
| 4. K.J. Osborn, MIN | 884 | |
| 5. Stefon Diggs, BUF | 875 | |
League Leaders - Defense
| Tackles | Complete List | |
Germaine Pratt
|
1. Germaine Pratt, CIN | 79 |
| 2. Tremaine Edmunds, CHI | 72 | |
| 3. Matt Milano, BUF | 72 | |
| 4. Demario Davis, NO | 71 | |
| 5. Divine Deablo, LV | 68 | |
| Sacks | Complete List | |
Aaron Donald
|
1. Aaron Donald, LAR | 15 |
| 2. Khalil Mack, LAC | 13 | |
| 3. Joey Bosa, LAC | 10 | |
| 4. Myles Garrett, CLE | 10 | |
| 5. Quinnen Williams, NYJ | 9 | |
| Interceptions | Complete List | |
Devin White
|
1. Devin White, TB | 5 |
| 2. Stephon Gilmore, DAL | 4 | |
| 3. Marcus Peters, NE | 4 | |
| 4. Kendall Fuller, WAS | 4 | |
| 5. Kyle Hamilton, BAL | 4 | |