League Leaders - Offense
| Passing Yards | Complete List | |
Tavien St. Clair
|
1. Tavien St. Clair, SF | 5373 |
| 2. Jared Curtis, ATL | 4832 | |
| 3. Joe Burrow, CIN | 4822 | |
| 4. Caleb Williams, CHI | 4718 | |
| 5. J.J. McCarthy, TB | 4553 | |
| Rushing Yards | Complete List | |
Girard Pringle Jr
|
1. Girard Pringle Jr, SEA | 1519 |
| 2. Justice Haynes, DEN | 1433 | |
| 3. TreVeyon Henderson, CHI | 1389 | |
| 4. Alex Chambers, NE | 1283 | |
| 5. De'Von Achane, MIA | 1260 | |
| Receiving Yards | Complete List | |
Zach Harris
|
1. Zach Harris, SF | 1618 |
| 2. Ja'Marr Chase, CIN | 1493 | |
| 3. Micah Hudson, GB | 1436 | |
| 4. Squirrel White, SF | 1307 | |
| 5. Johntay Cook II, ATL | 1282 | |
League Leaders - Defense
| Tackles | Complete List | |
Steven Lambert
|
1. Steven Lambert, BAL | 112 |
| 2. Lander Barton, NYJ | 101 | |
| 3. Jaylon Carlies, MIN | 97 | |
| 4. Raylen Wilson, MIN | 97 | |
| 5. Tyler Atkinson, NYG | 96 | |
| Sacks | Complete List | |
T.J. Parker
|
1. T.J. Parker, LV | 19 |
| 2. Nick Bosa, JAX | 15 | |
| 3. Myles Garrett, TB | 15 | |
| 4. Kenneth Grant, WAS | 14 | |
| 5. Travon Walker, NO | 14 | |
| Interceptions | Complete List | |
Tre'von Moehrig
|
1. Tre'von Moehrig, SF | 10 |
| 2. Drew Sanders, DEN | 7 | |
| 3. Jeremiah Gibson, MIA | 6 | |
| 4. Devon Witherspoon, MIN | 6 | |
| 5. Trevin Wallace, LV | 6 | |