League Leaders - Offense
| Passing Yards | Complete List | |
Shane Maziejka
|
1. Shane Maziejka, MEX | 6636 |
| 2. Jay Rich, TOR | 6372 | |
| 3. Danny Pope, CHO | 6356 | |
| 4. Jayden Daniels, VAN | 5820 | |
| 5. Desmond Ridder, HOU | 5524 | |
| Rushing Yards | Complete List | |
Eddie Watters
|
1. Eddie Watters, HOU | 1738 |
| 2. Corey Short, ATL | 1701 | |
| 3. Tavaris Brown, CIN | 1275 | |
| 4. Jalen McDougal, NYG | 1267 | |
| 5. Donte Banks, MEX2 | 1241 | |
| Receiving Yards | Complete List | |
Matt Streaks
|
1. Matt Streaks, ORL2 | 2350 |
| 2. Devon Moore, ATL | 2252 | |
| 3. Lawrence Edwards, PHI | 2232 | |
| 4. Devon Newberry, SA2 | 2098 | |
| 5. Melvin Wakefield, CHO | 2047 | |
League Leaders - Defense
| Tackles | Complete List | |
William Pace
|
1. William Pace, SA | 100 |
| 2. Junior Colson, ANC | 98 | |
| 3. Juwan Wheatley, TKY | 91 | |
| 4. Andrew Whiteside, CHO2 | 88 | |
| 5. Klay Woods, HST2 | 82 | |
| Sacks | Complete List | |
Tashaun Sheppard
|
1. Tashaun Sheppard, HOU | 21 |
| 2. Nick Bosa, OMH | 18 | |
| 3. Jonathan Woodley, MIA | 18 | |
| 4. Tavaris Clemons, TOR | 16 | |
| 5. John Abraham jr, ATL | 15 | |
| Interceptions | Complete List | |
Benjamin Gary
|
1. Benjamin Gary, VAN | 12 |
| 2. Deion Sanders Jr, ATL | 11 | |
| 3. Trent McDuffie, ATL | 11 | |
| 4. Edgerrin Cooper, HOU | 11 | |
| 5. Trevor Bell, IND | 10 | |