League Leaders - Offense
| Passing Yards | Complete List | |
Drake Maye
|
1. Drake Maye, SA | 2939 |
| 2. Shane Maziejka, MEX | 2791 | |
| 3. Jay Rich, TOR | 2769 | |
| 4. LO Washington, ORL | 2633 | |
| 5. C.J. Stroud, SA2 | 2498 | |
| Rushing Yards | Complete List | |
Trey Benson
|
1. Trey Benson, OMH | 1415 |
| 2. Corey Short, ATL | 1031 | |
| 3. Tavaris Brown, CIN | 984 | |
| 4. Trent Abraham, SA2 | 896 | |
| 5. Eddie Watters, HOU | 660 | |
| Receiving Yards | Complete List | |
Devon Moore
|
1. Devon Moore, ATL | 1089 |
| 2. Xavier Worthy, ORL | 893 | |
| 3. Matthew Stallworth, SA2 | 881 | |
| 4. Jeffrey Foote, TOR | 879 | |
| 5. Keon Coleman, SA | 760 | |
League Leaders - Defense
| Tackles | Complete List | |
Jerry Goodson
|
1. Jerry Goodson, KC | 44 |
| 2. Klay Woods, HST2 | 44 | |
| 3. Zach Chapman, HST2 | 40 | |
| 4. Ernest Himmingway, HST2 | 39 | |
| 5. Jeremiah Owusu-Koramoah, NYG | 38 | |
| Sacks | Complete List | |
Nick Bosa
|
1. Nick Bosa, OMH | 11 |
| 2. Matthew Hennings, LOU | 10 | |
| 3. Donald Houser, BUF | 10 | |
| 4. Trevor Bigsby, MEX2 | 9 | |
| 5. Marcus Wall, SA2 | 9 | |
| Interceptions | Complete List | |
Quinyon Mitchell
|
1. Quinyon Mitchell, IND | 12 |
| 2. Channing Tindall, CIN | 9 | |
| 3. Edgerrin Cooper, SA | 8 | |
| 4. Ruben Phillips, CIN | 8 | |
| 5. Tyreke Copper, OMH | 7 | |