League Leaders - Offense
| Passing Yards | Complete List | |
Will Beamen Jr.
|
1. Will Beamen Jr., GB | 5944 |
| 2. Anthony Richardson, IND | 4697 | |
| 3. Travis Rogan, ATL | 4468 | |
| 4. Nate Heath, LV | 4234 | |
| 5. Hendon Hooker, NYG | 4180 | |
| Rushing Yards | Complete List | |
Travis Etienne Jr
|
1. Travis Etienne Jr, LAR | 2203 |
| 2. Khalil Herbert, CHI | 1989 | |
| 3. Kenneth Walker III, SEA | 1639 | |
| 4. Jahmyr Gibbs, DET | 1595 | |
| 5. Breece Hall, NYJ | 1563 | |
| Receiving Yards | Complete List | |
Jimmy Sanderson II
|
1. Jimmy Sanderson II, GB | 1776 |
| 2. Tyreek Hill, GB | 1384 | |
| 3. Deebo Samuel Sr, SF | 1343 | |
| 4. Jimmy Hyde, PHI | 1285 | |
| 5. Chris Olave, NO | 1259 | |
League Leaders - Defense
| Tackles | Complete List | |
Drew Sanders
|
1. Drew Sanders, DEN | 99 |
| 2. Roquan Smith, BAL | 96 | |
| 3. Gabe Rucker, NYJ | 73 | |
| 4. Keilan Kirksey, DEN | 70 | |
| 5. Jerome Jackson, DEN | 70 | |
| Sacks | Complete List | |
Kwity Paye
|
1. Kwity Paye, IND | 17 |
| 2. Josh Allen, CIN | 14 | |
| 3. Derrick Wiggins, NYJ | 13 | |
| 4. Myles Garrett, PHI | 13 | |
| 5. Azeez Ojulari, ATL | 12 | |
| Interceptions | Complete List | |
Jalen Ramsey
|
1. Jalen Ramsey, LAR | 14 |
| 2. Julius Brents, IND | 9 | |
| 3. Devon Witherspoon, SEA | 9 | |
| 4. Rodney Thomas II, IND | 8 | |
| 5. Isaiah Hewitt, GB | 8 | |