League Leaders - Offense
| Passing Yards | Complete List | |
Caleb Williams
|
1. Caleb Williams, CHI | 1421 |
| 2. Josh Allen, BUF | 1053 | |
| 3. C.J. Stroud, HOU | 988 | |
| 4. Carson Beck, LV | 985 | |
| 5. DJ Uaigalelei, TB | 970 | |
| Rushing Yards | Complete List | |
Rachaad White
|
1. Rachaad White, TB | 408 |
| 2. Tahj Brooks, DAL | 363 | |
| 3. Josh Jacobs, BUF | 315 | |
| 4. DaShaun Harris, NE | 305 | |
| 5. Trumaine Bernard, LAR | 284 | |
| Receiving Yards | Complete List | |
Rome Odunze
|
1. Rome Odunze, CHI | 872 |
| 2. Tetairoa McMillan, HOU | 469 | |
| 3. Markus Mills, NYJ | 465 | |
| 4. Oscar Delp, CLE | 428 | |
| 5. Christian Watson, GB | 406 | |
League Leaders - Defense
| Tackles | Complete List | |
Troy Andersen
|
1. Troy Andersen, ATL | 15 |
| 2. Roquan Smith, BAL | 14 | |
| 3. Trenton Simpson, BAL | 14 | |
| 4. Jaylen Reed, CHI | 13 | |
| 5. Jake Messina, IND | 13 | |
| Sacks | Complete List | |
Harold Perkins Jr
|
1. Harold Perkins Jr, BUF | 6 |
| 2. Joe Tryon-Shoyinka, TB | 5 | |
| 3. Maxx Crosby, LV | 4 | |
| 4. Byron Young, LAR | 4 | |
| 5. Matt Benedict, CLE | 4 | |
| Interceptions | Complete List | |
Xavier Watts
|
1. Xavier Watts, PHI | 5 |
| 2. Omar Speights, LAR | 5 | |
| 3. Dakota Stein, TB | 4 | |
| 4. Roger McCreary, CHI | 3 | |
| 5. Matt Milano, BUF | 3 | |