League Leaders - Offense
| Passing Yards | Complete List | |
Caleb Williams
|
1. Caleb Williams, CHI | 5395 |
| 2. Patrick Mahomes, KC | 4847 | |
| 3. J.J. McCarthy, MIN | 4816 | |
| 4. Deshaun Watson, CLE | 4797 | |
| 5. Drew Allar, NYJ | 4390 | |
| Rushing Yards | Complete List | |
Trumaine Bernard
|
1. Trumaine Bernard, LAR | 1419 |
| 2. Jahmyr Gibbs, DET | 1290 | |
| 3. Doug Mitchell, PHI | 1267 | |
| 4. Isaac Guerendo, SF | 1252 | |
| 5. Rachaad White, TB | 1228 | |
| Receiving Yards | Complete List | |
Emeka Egbuka
|
1. Emeka Egbuka, MIN | 2571 |
| 2. Oscar Delp, CLE | 2109 | |
| 3. Rome Odunze, CHI | 1733 | |
| 4. Troy Franklin, DEN | 1489 | |
| 5. Evan Stewart, PHI | 1460 | |
League Leaders - Defense
| Tackles | Complete List | |
Jordan Battle
|
1. Jordan Battle, CIN | 94 |
| 2. Kenneth Murray Jr, TEN | 93 | |
| 3. Logan Wilson, CIN | 89 | |
| 4. Demario Davis, NO | 78 | |
| 5. L'Jarius Sneed, TEN | 77 | |
| Sacks | Complete List | |
Haason Reddick
|
1. Haason Reddick, NYJ | 14 |
| 2. Calijah Kancey, TB | 13 | |
| 3. Josh Hines-Allen, JAX | 13 | |
| 4. Montez Sweat, CHI | 12 | |
| 5. Aidan Hutchinson, DET | 12 | |
| Interceptions | Complete List | |
Trevon Diggs
|
1. Trevon Diggs, DAL | 10 |
| 2. Tyler Nubin, NYG | 8 | |
| 3. Tremaine Edmunds, CHI | 8 | |
| 4. Kris Abrams-Draine, DEN | 8 | |
| 5. Sauce Gardner, NYJ | 8 | |