League Leaders - Offense
| Passing Yards | Complete List | |
Jared Goff
|
1. Jared Goff, DET | 2924 |
| 2. Mac Jones, NE | 2596 | |
| 3. Aaron Rodgers, NYJ | 2586 | |
| 4. Malik Willis, TEN | 2531 | |
| 5. Desmond Ridder, ATL | 2489 | |
| Rushing Yards | Complete List | |
Tyreek Hill
|
1. Tyreek Hill, MIA | 2017 |
| 2. Josh Jacobs, LV | 1951 | |
| 3. Derrick Henry, TEN | 1128 | |
| 4. Miles Sanders, CAR | 1111 | |
| 5. Aaron Jones, GB | 1003 | |
| Receiving Yards | Complete List | |
Garrett Wilson
|
1. Garrett Wilson, NYJ | 1019 |
| 2. Amon-Ra St. Brown, DET | 999 | |
| 3. Stefon Diggs, BUF | 863 | |
| 4. Jameson Williams, DET | 860 | |
| 5. Tyquan Thornton, NE | 830 | |
League Leaders - Defense
| Tackles | Complete List | |
Quincy Williams
|
1. Quincy Williams, NYJ | 40 |
| 2. Denzel Perryman, HOU | 37 | |
| 3. Terrell Edmunds, TEN | 37 | |
| 4. Jordan Poyer, BUF | 36 | |
| 5. Divine Deablo, LV | 35 | |
| Sacks | Complete List | |
T.J. Watt
|
1. T.J. Watt, PIT | 9 |
| 2. Brian Burns, CAR | 9 | |
| 3. Rashan Gary, GB | 8 | |
| 4. Myles Garrett, CLE | 7 | |
| 5. Josh Allen, JAX | 7 | |
| Interceptions | Complete List | |
C.J. Gardner-Johnson
|
1. C.J. Gardner-Johnson, DET | 9 |
| 2. Nate Hobbs, LV | 8 | |
| 3. Cory Trice Jr, CHI | 8 | |
| 4. A.J. Terrell Jr, ATL | 8 | |
| 5. Xavier Woods, CAR | 7 | |