League Leaders - Offense
| Passing Yards | Complete List | |
Hajj-Malik Williams
|
1. Hajj-Malik Williams, SF | 10455 |
| 2. Kordell Williams, DET | 6156 | |
| 3. Lamar Jackson, MIA | 6059 | |
| 4. Bo Nix, DEN | 5922 | |
| 5. Trevor Lawrence, JAX | 5490 | |
| Rushing Yards | Complete List | |
Jonathan Stockton
|
1. Jonathan Stockton, TEN | 1029 |
| 2. Isaiah Gore, LAC | 1028 | |
| 3. Juwan Bonner, CHI | 869 | |
| 4. Eric Browning, CLE | 836 | |
| 5. TreVeyon Henderson, MIA | 829 | |
| Receiving Yards | Complete List | |
Jeremiah Smith
|
1. Jeremiah Smith, SF | 3912 |
| 2. Henry Ruggs III, SF | 3195 | |
| 3. Nick Stovall, DET | 2359 | |
| 4. Dont'e Thornton Jr., SF | 2233 | |
| 5. Louis Brown, LAC | 2157 | |
League Leaders - Defense
| Tackles | Complete List | |
John Dixon
|
1. John Dixon, DEN | 74 |
| 2. Luke Kuechly, CAR | 73 | |
| 3. Gregory Gordon, CLE | 71 | |
| 4. Dominique Hampton, SEA | 64 | |
| 5. Drew Sanders, ATL | 62 | |
| Sacks | Complete List | |
Don Taylor
|
1. Don Taylor, SF | 38 |
| 2. Damarr Routt, SF | 24 | |
| 3. Nolan Smith Jr, WAS | 21 | |
| 4. Je'von Kearse, WAS | 20 | |
| 5. Jonah Elliss, DEN | 17 | |
| Interceptions | Complete List | |
Champ Bailey
|
1. Champ Bailey, TEN | 11 |
| 2. Nnamdi Asomugha Jr., SF | 11 | |
| 3. Glenn Simmons, DET | 10 | |
| 4. Damien Bruce, TEN | 9 | |
| 5. Prime Time, TEN | 9 | |