League Leaders - Offense
| Passing Yards | Complete List | |
Brock Purdy
|
1. Brock Purdy, SF | 5229 |
| 2. Jordan Love, TKY2 | 4826 | |
| 3. Jeff Blake, CHO | 4637 | |
| 4. Justin Herbert, LAC | 4583 | |
| 5. Anthony Richardson, IND | 4571 | |
| Rushing Yards | Complete List | |
Jonathan Taylor
|
1. Jonathan Taylor, IND | 1666 |
| 2. Bo Jackson, LV | 1625 | |
| 3. Nick Chubb, CLE | 1508 | |
| 4. Ahmad Green Jr, TKY2 | 1469 | |
| 5. Saquon Barkley, NYG | 1463 | |
| Receiving Yards | Complete List | |
Jamie Jennings
|
1. Jamie Jennings, SF | 1756 |
| 2. John Brown, CHO | 1461 | |
| 3. Amari Justice, IND | 1366 | |
| 4. Quez Watkins, PHI | 1349 | |
| 5. Dionte Phillips, LAC | 1330 | |
League Leaders - Defense
| Tackles | Complete List | |
Silas Levy
|
1. Silas Levy, CIN | 87 |
| 2. DJ Turner, CIN | 74 | |
| 3. Devin Bush, PIT | 73 | |
| 4. Akeem Davis-Gaither, MIN | 72 | |
| 5. Tyrone Bayless, CIN | 71 | |
| Sacks | Complete List | |
Darnell Dockett
|
1. Darnell Dockett, MIA | 16 |
| 2. Joe Tryon-Shoyinka, TKY | 14 | |
| 3. Maxx Crosby, LV | 14 | |
| 4. Aidan Hutchinson, DET | 13 | |
| 5. Owen Pappoe, CHO | 13 | |
| Interceptions | Complete List | |
Lionel Starling
|
1. Lionel Starling, SF | 12 |
| 2. Greg Newsome II, MIN | 10 | |
| 3. Talanoa Hufanga, SF | 10 | |
| 4. Deonte Banks, NYG | 10 | |
| 5. Andre Cisco, VB | 10 | |