League Leaders - Offense
| Passing Yards | Complete List | |
Patrick Mahomes
|
1. Patrick Mahomes, DUB | 5198 |
| 2. Justin Herbert, LAC | 4819 | |
| 3. Kenny Pickett, PIT | 4686 | |
| 4. Joe Burrow, OAK | 4490 | |
| 5. Josh Allen, BKN | 4448 | |
| Rushing Yards | Complete List | |
Jonathan Taylor
|
1. Jonathan Taylor, IND | 1904 |
| 2. Kenneth Walker III, SEA | 1849 | |
| 3. Breece Hall, SJU | 1675 | |
| 4. Bijan Robinson, ATL | 1655 | |
| 5. Deshawn Grimes, TOR | 1622 | |
| Receiving Yards | Complete List | |
Keon Coleman
|
1. Keon Coleman, LAC | 1502 |
| 2. George Pickens, PIT | 1460 | |
| 3. Zay Flowers, HST | 1391 | |
| 4. Bryan Nance, OAK | 1357 | |
| 5. Chris Olave, NO | 1325 | |
League Leaders - Defense
| Tackles | Complete List | |
Rich McKinney
|
1. Rich McKinney, VB | 112 |
| 2. Cory Morris, ARI | 108 | |
| 3. Pat Willis, BKN | 107 | |
| 4. Aaron LeBlanc, CHI | 99 | |
| 5. Clayton Stratton, IND | 97 | |
| Sacks | Complete List | |
Greg Rousseau
|
1. Greg Rousseau, OAK | 17 |
| 2. Jeffery Simmons, PIT | 17 | |
| 3. Quinnen Williams, SJU | 15 | |
| 4. Danielle Hunter, DUB | 13 | |
| 5. T.J. Watt, PIT | 13 | |
| Interceptions | Complete List | |
Denzel Ward
|
1. Denzel Ward, LAR | 8 |
| 2. Devon Witherspoon, SEA | 7 | |
| 3. Gabe Buchanan, DUB | 7 | |
| 4. Jason Crossen, SJU | 7 | |
| 5. Emmanuel Forbes Jr, TOR3 | 6 | |