League Leaders - Offense
| Passing Yards | Complete List | |
Brock Purdy
|
1. Brock Purdy, SF | 1250 |
| 2. Josh Allen, BUF | 1021 | |
| 3. Shedeur Sanders, CLE | 982 | |
| 4. Tommy Mellott, LV | 944 | |
| 5. J.J. McCarthy, MIN | 891 | |
| Rushing Yards | Complete List | |
Breece Hall
|
1. Breece Hall, NYJ | 238 |
| 2. James Cook, BUF | 229 | |
| 3. Isiah Pacheco, KC | 198 | |
| 4. Bijan Robinson, ATL | 170 | |
| 5. Derrick Henry, BAL | 168 | |
| Receiving Yards | Complete List | |
Ricky Pearsall
|
1. Ricky Pearsall, SF | 463 |
| 2. Xavier Worthy, KC | 443 | |
| 3. T.J. Hockenson, MIN | 386 | |
| 4. Tyler Harrell, LV | 350 | |
| 5. D.K. Metcalf, PIT | 337 | |
League Leaders - Defense
| Tackles | Complete List | |
Jeremy Chinn
|
1. Jeremy Chinn, LV | 17 |
| 2. Micah Parsons, DAL | 17 | |
| 3. Germaine Pratt, CIN | 16 | |
| 4. Kyzir White, ARI | 16 | |
| 5. Terrel Bernard, BUF | 15 | |
| Sacks | Complete List | |
Montez Sweat
|
1. Montez Sweat, CHI | 4 |
| 2. Greg Rousseau, BUF | 4 | |
| 3. Terrel Bernard, BUF | 3 | |
| 4. Kwon Alexander, JAX | 3 | |
| 5. Jaelan Phillips, MIA | 3 | |
| Interceptions | Complete List | |
Trent McDuffie
|
1. Trent McDuffie, KC | 4 |
| 2. Cooper DeJean, PHI | 4 | |
| 3. Jaden Hicks, KC | 3 | |
| 4. Kenny Moore II, IND | 3 | |
| 5. Cole Bishop, BUF | 3 | |