League Leaders - Offense
| Passing Yards | Complete List | |
Will Howard
|
1. Will Howard, PIT | 1394 |
| 2. J.J. McCarthy, MIN | 1269 | |
| 3. Brock Purdy, SF | 1250 | |
| 4. Michael Penix Jr, ATL | 1214 | |
| 5. Jalen Hurts, PHI | 1209 | |
| Rushing Yards | Complete List | |
Breece Hall
|
1. Breece Hall, NYJ | 416 |
| 2. Blake Corum, LAR | 272 | |
| 3. Travis Etienne Jr, JAX | 260 | |
| 4. Kaleb Johnson, PIT | 234 | |
| 5. James Cook, BUF | 229 | |
| Receiving Yards | Complete List | |
Xavier Worthy
|
1. Xavier Worthy, KC | 677 |
| 2. D.K. Metcalf, PIT | 607 | |
| 3. T.J. Hockenson, MIN | 471 | |
| 4. Ricky Pearsall, SF | 463 | |
| 5. DeVonta Smith, PHI | 399 | |
League Leaders - Defense
| Tackles | Complete List | |
Micah Parsons
|
1. Micah Parsons, DAL | 20 |
| 2. Kyzir White, ARI | 18 | |
| 3. Germaine Pratt, CIN | 18 | |
| 4. Jeremy Chinn, LV | 17 | |
| 5. Cole Holcomb, PIT | 16 | |
| Sacks | Complete List | |
Montez Sweat
|
1. Montez Sweat, CHI | 4 |
| 2. Greg Rousseau, BUF | 4 | |
| 3. Khalil Mack, LAC | 3 | |
| 4. Drake Jackson, DAL | 3 | |
| 5. Terrel Bernard, BUF | 3 | |
| Interceptions | Complete List | |
Cooper DeJean
|
1. Cooper DeJean, PHI | 7 |
| 2. Trent McDuffie, KC | 5 | |
| 3. Jaden Hicks, KC | 4 | |
| 4. Minkah Fitzpatrick, PIT | 4 | |
| 5. Patrick Queen, PIT | 4 | |